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- W1997746557 abstract "Recurrent respiratory papillomatosis (RRP) is a relatively rare disease caused by members of the human papilloma virus (HPV) family.32, 67, 76 Characterized by the growth of wart-like excrescences in the aerodigestive tract, RRP shows a tremendous predilection for the larynx and is the most common neoplasm to affect this organ in the pediatric population.20 Hoarseness is the heralding symptom of RRP, although some children do not present until they are completely aphonic or develop life-threatening airway obstruction. Despite a benign histologic appearance, the clinical course of RRP is typified by relentless recurrences even after seemingly complete surgical excision. The impact of RRP on patients, their families, and the health care system is immense. RRP affects an estimated 6000 children in the United States, and its management produces an annual cost of nearly $110 million.24 Despite extensive investigational studies, no cure is available. Surgical excision is the mainstay of therapy but is generally only a temporizing measure. Laser vaporization of papillomata is performed every few months to preserve phonation and prevent asphyxiation, although disease exacerbations may necessitate more common procedures. Ultimately, most children enter spontaneous remission, but the age and severity of disease prior to this reprieve are variable and unpredictable. Disheartening recurrences may emerge even years after disease remission. This article presents the unique characteristics of RRP, including its cause, mode of transmission, pathogenesis, clinical features, histologic appearance, treatment strategies, and outcome." @default.
- W1997746557 created "2016-06-24" @default.
- W1997746557 creator A5014833790 @default.
- W1997746557 creator A5061524606 @default.
- W1997746557 date "1996-12-01" @default.
- W1997746557 modified "2023-09-24" @default.
- W1997746557 title "RECURRENT RESPIRATORY PAPILLOMATOSIS" @default.
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- W1997746557 doi "https://doi.org/10.1016/s0031-3955(05)70524-1" @default.
- W1997746557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8973518" @default.
- W1997746557 hasPublicationYear "1996" @default.
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