Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997749870> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W1997749870 endingPage "266" @default.
- W1997749870 startingPage "257" @default.
- W1997749870 abstract "Cocaine administration elicits a pressor response reportedly dependent upon central and peripheral actions. The present study was designed specifically to determine whether cocaine affects baroreflex sensitivity and whether this is mediated by an action in the CNS. Baroreflex control of heart rate was assessed by noting the change in the duration of the arterial pulse pressure or in the heart rate elicited by administration of pressor and depressor agents. The effects of intracerebroventricular and intravenous cocaine administration were compared. Cocaine (0.1-0.15 mg/kg/min, i.v.) produced a decrease in baroreflex sensitivity that was greater than that produced by an approximately equipressor infusion of phenylephrine (0.5-1.3 micrograms/kg/min, i.v.). Intracerebroventricular (i.c.v.) administration of cocaine (1.5-150 micrograms) or procaine (100 micrograms) had no effect on arterial pressure, heart rate or baroreflex control of heart rate. Furthermore, central administration of yohimbine (3 and 10 micrograms, i.c.v.) was capable of preventing the suppression of the heart rate responses induced by cocaine administration. Propranolol (15 micrograms, i.c.v.) was not able to attenuate the suppression of baroreflex sensitivity elicited by intravenous cocaine administration but higher doses (50-150 micrograms, i.c.v.) could mimic this effect. These data suggest that cocaine suppresses baroreflex control of heart rate by a central alpha 2-adrenergic mechanism. In contrast, the pressor response to intravenous cocaine is not likely to be dependent upon a forebrain periventricular site." @default.
- W1997749870 created "2016-06-24" @default.
- W1997749870 creator A5029004052 @default.
- W1997749870 creator A5056387288 @default.
- W1997749870 creator A5064236865 @default.
- W1997749870 date "1993-06-01" @default.
- W1997749870 modified "2023-10-14" @default.
- W1997749870 title "Effects of cocaine on baroreflex control of heart rate in conscious rats" @default.
- W1997749870 cites W1930820485 @default.
- W1997749870 cites W1973818213 @default.
- W1997749870 cites W1984301745 @default.
- W1997749870 cites W1990892522 @default.
- W1997749870 cites W1991078771 @default.
- W1997749870 cites W1998411936 @default.
- W1997749870 cites W2007893159 @default.
- W1997749870 cites W2016692098 @default.
- W1997749870 cites W2018911285 @default.
- W1997749870 cites W2023325653 @default.
- W1997749870 cites W2027802482 @default.
- W1997749870 cites W2032728512 @default.
- W1997749870 cites W2033489568 @default.
- W1997749870 cites W2049162381 @default.
- W1997749870 cites W2051063332 @default.
- W1997749870 cites W2059454036 @default.
- W1997749870 cites W2066033102 @default.
- W1997749870 cites W2070791779 @default.
- W1997749870 cites W2077461364 @default.
- W1997749870 cites W2080208020 @default.
- W1997749870 cites W2125831111 @default.
- W1997749870 cites W2138851126 @default.
- W1997749870 cites W2168633042 @default.
- W1997749870 cites W2298004578 @default.
- W1997749870 cites W2423942202 @default.
- W1997749870 cites W4206659802 @default.
- W1997749870 doi "https://doi.org/10.1016/0165-1838(93)90332-o" @default.
- W1997749870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8103533" @default.
- W1997749870 hasPublicationYear "1993" @default.
- W1997749870 type Work @default.
- W1997749870 sameAs 1997749870 @default.
- W1997749870 citedByCount "16" @default.
- W1997749870 crossrefType "journal-article" @default.
- W1997749870 hasAuthorship W1997749870A5029004052 @default.
- W1997749870 hasAuthorship W1997749870A5056387288 @default.
- W1997749870 hasAuthorship W1997749870A5064236865 @default.
- W1997749870 hasConcept C126322002 @default.
- W1997749870 hasConcept C170493617 @default.
- W1997749870 hasConcept C191237925 @default.
- W1997749870 hasConcept C2776885963 @default.
- W1997749870 hasConcept C2777676773 @default.
- W1997749870 hasConcept C2777952589 @default.
- W1997749870 hasConcept C2777953023 @default.
- W1997749870 hasConcept C2778151854 @default.
- W1997749870 hasConcept C42219234 @default.
- W1997749870 hasConcept C71924100 @default.
- W1997749870 hasConcept C84393581 @default.
- W1997749870 hasConceptScore W1997749870C126322002 @default.
- W1997749870 hasConceptScore W1997749870C170493617 @default.
- W1997749870 hasConceptScore W1997749870C191237925 @default.
- W1997749870 hasConceptScore W1997749870C2776885963 @default.
- W1997749870 hasConceptScore W1997749870C2777676773 @default.
- W1997749870 hasConceptScore W1997749870C2777952589 @default.
- W1997749870 hasConceptScore W1997749870C2777953023 @default.
- W1997749870 hasConceptScore W1997749870C2778151854 @default.
- W1997749870 hasConceptScore W1997749870C42219234 @default.
- W1997749870 hasConceptScore W1997749870C71924100 @default.
- W1997749870 hasConceptScore W1997749870C84393581 @default.
- W1997749870 hasIssue "3" @default.
- W1997749870 hasLocation W19977498701 @default.
- W1997749870 hasLocation W19977498702 @default.
- W1997749870 hasOpenAccess W1997749870 @default.
- W1997749870 hasPrimaryLocation W19977498701 @default.
- W1997749870 hasRelatedWork W1989186466 @default.
- W1997749870 hasRelatedWork W2011791838 @default.
- W1997749870 hasRelatedWork W2017518158 @default.
- W1997749870 hasRelatedWork W2055207038 @default.
- W1997749870 hasRelatedWork W2057743834 @default.
- W1997749870 hasRelatedWork W2066123595 @default.
- W1997749870 hasRelatedWork W2332412760 @default.
- W1997749870 hasRelatedWork W2390404307 @default.
- W1997749870 hasRelatedWork W2423942202 @default.
- W1997749870 hasRelatedWork W646054279 @default.
- W1997749870 hasVolume "43" @default.
- W1997749870 isParatext "false" @default.
- W1997749870 isRetracted "false" @default.
- W1997749870 magId "1997749870" @default.
- W1997749870 workType "article" @default.