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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997754805> ?p ?o ?g. }

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• W1997754805 abstract "A new type of microscope objective is used for the rapid detection of sequence-dependent affinity variations in DNA hybridization. We demonstrate that by performing probe/target hybridization on coverslips at room temperature terminal SNPs (single nucleotide polymorphisms) can be detected within seconds. The study of weak pair interaction, such as the association of very short DNA oligomers, requires the use of high analyte concentrations of both partners to generate a detectable amount of associated pairs. The background of high concentrations of unbound fluorescing analyte can easily hide the low signal of a weakly affine reaction and makes association extremely difficult to detect. Fluorescence detection is a powerful approach to analyze minute amounts of material, even single molecules, but it is usually limited to rather low concentrations. This limitation is now overcome due to the new type of microscope objective, which produces an extremely small detection volume at a water/glass interface." @default.
• W1997754805 created "2016-06-24" @default.
• W1997754805 creator A5043992082 @default.
• W1997754805 creator A5055252610 @default.
• W1997754805 date "2005-03-08" @default.
• W1997754805 modified "2023-09-25" @default.
• W1997754805 title "Microscope Objective for Large-Angle Fluorescence Used for Rapid Detection of Single Nucleotide Polymorphisms in DNA Hybridization" @default.
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• W1997754805 doi "https://doi.org/10.1021/ac048404n" @default.
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