Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997758531> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W1997758531 endingPage "220" @default.
- W1997758531 startingPage "216" @default.
- W1997758531 abstract "The variables that influence the tablets obtained by direct compression method deserve to be studied to minimize formulations costs and to improve the physicochemical and biopharmaceutical properties of the compacts. Here, we explore the adjuvants effects on amoxicillin tablet formulations considering multiple responses, and indicate the most suitable formulation composition. A 2(3) full factorial design was built to different amoxicillin formulations, each one containing three replicate batches, and eight responses (physicochemical and biopharmaceutical parameters) were obtained. The microcrystalline cellulose (MCC) type Avicel PH-102 (low) or PH-200 (high), the absence (low) or presence (high) of spray-dried lactose (LAC), and the absence (low) or presence (high) of disintegrant (DIS) were the levels investigated. The more relevant responses to the distinct formulations from the experimental design were hardness, friability, and the amount of amoxicillin dissolved during the first hour. PCA biplot indicated high values of amount of drug dissolved in 60 min as advantageous responses for the investigated amoxicillin tablet formulations and high values of friability as not desirable. Considering the individual response evaluation, the most suitable amoxicillin tablet formulation should present in its composition the MCC type Avicel PH-102 (low level) and the superdisintegrant agent (DIS high level), croscarmellose sodium, but no LAC (low level)." @default.
- W1997758531 created "2016-06-24" @default.
- W1997758531 creator A5001869460 @default.
- W1997758531 creator A5002047002 @default.
- W1997758531 creator A5022436732 @default.
- W1997758531 creator A5034461340 @default.
- W1997758531 creator A5060024705 @default.
- W1997758531 date "2007-07-01" @default.
- W1997758531 modified "2023-10-01" @default.
- W1997758531 title "A study of physicochemical and biopharmaceutical properties of Amoxicillin tablets using full factorial design and PCA biplot" @default.
- W1997758531 cites W1973535761 @default.
- W1997758531 cites W1984436548 @default.
- W1997758531 cites W2006901874 @default.
- W1997758531 cites W2036072333 @default.
- W1997758531 cites W2084372072 @default.
- W1997758531 cites W2104146802 @default.
- W1997758531 cites W2154878628 @default.
- W1997758531 doi "https://doi.org/10.1016/j.aca.2007.03.065" @default.
- W1997758531 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17606003" @default.
- W1997758531 hasPublicationYear "2007" @default.
- W1997758531 type Work @default.
- W1997758531 sameAs 1997758531 @default.
- W1997758531 citedByCount "12" @default.
- W1997758531 countsByYear W19977585312014 @default.
- W1997758531 countsByYear W19977585312018 @default.
- W1997758531 countsByYear W19977585312019 @default.
- W1997758531 countsByYear W19977585312020 @default.
- W1997758531 countsByYear W19977585312021 @default.
- W1997758531 countsByYear W19977585312022 @default.
- W1997758531 crossrefType "journal-article" @default.
- W1997758531 hasAuthorship W1997758531A5001869460 @default.
- W1997758531 hasAuthorship W1997758531A5002047002 @default.
- W1997758531 hasAuthorship W1997758531A5022436732 @default.
- W1997758531 hasAuthorship W1997758531A5034461340 @default.
- W1997758531 hasAuthorship W1997758531A5060024705 @default.
- W1997758531 hasConcept C104317684 @default.
- W1997758531 hasConcept C105795698 @default.
- W1997758531 hasConcept C118483189 @default.
- W1997758531 hasConcept C135763542 @default.
- W1997758531 hasConcept C150903083 @default.
- W1997758531 hasConcept C169222746 @default.
- W1997758531 hasConcept C178790620 @default.
- W1997758531 hasConcept C185592680 @default.
- W1997758531 hasConcept C191168616 @default.
- W1997758531 hasConcept C2776035855 @default.
- W1997758531 hasConcept C2779251873 @default.
- W1997758531 hasConcept C2779351475 @default.
- W1997758531 hasConcept C2779708577 @default.
- W1997758531 hasConcept C2781047461 @default.
- W1997758531 hasConcept C33923547 @default.
- W1997758531 hasConcept C43617362 @default.
- W1997758531 hasConcept C501593827 @default.
- W1997758531 hasConcept C521977710 @default.
- W1997758531 hasConcept C55493867 @default.
- W1997758531 hasConcept C77281830 @default.
- W1997758531 hasConcept C86803240 @default.
- W1997758531 hasConceptScore W1997758531C104317684 @default.
- W1997758531 hasConceptScore W1997758531C105795698 @default.
- W1997758531 hasConceptScore W1997758531C118483189 @default.
- W1997758531 hasConceptScore W1997758531C135763542 @default.
- W1997758531 hasConceptScore W1997758531C150903083 @default.
- W1997758531 hasConceptScore W1997758531C169222746 @default.
- W1997758531 hasConceptScore W1997758531C178790620 @default.
- W1997758531 hasConceptScore W1997758531C185592680 @default.
- W1997758531 hasConceptScore W1997758531C191168616 @default.
- W1997758531 hasConceptScore W1997758531C2776035855 @default.
- W1997758531 hasConceptScore W1997758531C2779251873 @default.
- W1997758531 hasConceptScore W1997758531C2779351475 @default.
- W1997758531 hasConceptScore W1997758531C2779708577 @default.
- W1997758531 hasConceptScore W1997758531C2781047461 @default.
- W1997758531 hasConceptScore W1997758531C33923547 @default.
- W1997758531 hasConceptScore W1997758531C43617362 @default.
- W1997758531 hasConceptScore W1997758531C501593827 @default.
- W1997758531 hasConceptScore W1997758531C521977710 @default.
- W1997758531 hasConceptScore W1997758531C55493867 @default.
- W1997758531 hasConceptScore W1997758531C77281830 @default.
- W1997758531 hasConceptScore W1997758531C86803240 @default.
- W1997758531 hasIssue "1-2" @default.
- W1997758531 hasLocation W19977585311 @default.
- W1997758531 hasLocation W19977585312 @default.
- W1997758531 hasOpenAccess W1997758531 @default.
- W1997758531 hasPrimaryLocation W19977585311 @default.
- W1997758531 hasRelatedWork W1491287169 @default.
- W1997758531 hasRelatedWork W1575700777 @default.
- W1997758531 hasRelatedWork W1997758531 @default.
- W1997758531 hasRelatedWork W2003097450 @default.
- W1997758531 hasRelatedWork W2115041881 @default.
- W1997758531 hasRelatedWork W2321956806 @default.
- W1997758531 hasRelatedWork W2557160209 @default.
- W1997758531 hasRelatedWork W3176088525 @default.
- W1997758531 hasRelatedWork W4313437971 @default.
- W1997758531 hasRelatedWork W2519048431 @default.
- W1997758531 hasVolume "595" @default.
- W1997758531 isParatext "false" @default.
- W1997758531 isRetracted "false" @default.
- W1997758531 magId "1997758531" @default.
- W1997758531 workType "article" @default.