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- W1997758843 abstract "Tin complexes of meso-substituted synthetic porphyrins, namely Sn 4+ -meso-tetraphenyl- porphyrin ( Sn - TPP ) and Sn 4+ -meso-tetrakis(N-methyl-3-pyridyl)porphyrin tetratosylate ( Sn - TMe -3- PyP ), efficiently decrease the serum bilirubin level when injected subcutaneously at a dose of 100 μM kg −1 body weight into mice. These compounds are active during hyperbilirubinemia, induced by phenylhydrazine, hemin and tetrachloromethane, and also during autoimmune hemolytic anemia. In the latter case a decrease in serum bilirubin content was observed, as well as a decrease in the amount of blood reticulocytes which reflects a milder course of the disease. The Sn complexes under study induce, in vivo, cytochrome P-450, inhibit microsomal heme oxygenase and decrease the intensity of lipid peroxidation. At the same time, in vitro the hepatic and splenic heme oxygenase activity is blocked only when a 0.1 μM concentration of Sn - TMe -3- PyP or Sn -protoporphyrin IX is added to the incubation mixture. Sn - TPP does not affect the activity of this enzyme in vitro." @default.
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- W1997758843 date "2000-04-01" @default.
- W1997758843 modified "2023-10-03" @default.
- W1997758843 title "The protective properties of synthetic porphyrin tin complexes in toxic hyperbilirubinemia" @default.
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- W1997758843 doi "https://doi.org/10.1002/(sici)1099-1409(200004/05)4:3<243::aid-jpp201>3.0.co;2-d" @default.
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