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- W1997766734 abstract "Atrial fibrillation (AF) affects more than six million people in the United States alone. It is associated with palpitations, reduced exercise tolerance, and dyspnea. Hemodynamic impairment results from loss of synchronous atrial contraction and rapid, irregular ventricular rates. Thromboembolism and stroke are serious complications. AF has been estimated to cause nearly 40% of all strokes in patients older than 70 years. 1 Wolf P.A. Abbott R.D. Kannel W.B. Atrial fibrillation as independent risk factor for stroke the Framingham Study. Stroke. 1991; 22: 983-988 Crossref PubMed Scopus (5656) Google Scholar Billions of health care dollars are spent each year on the care of patients with this arrhythmia and its sequelae. The incidence of AF increases with age. It induces anatomic and electrical remodeling of the atria. Myocyte degeneration, focal accumulation of endoplasmic reticulum and mitochondria, widening of portions of the intercalated discs, and replacement of myofibrils lead to patchy fibrosis, atrial dilatation, and myopathy. The atrial refractory period shortens. There is loss of the normal adaptation of refractoriness to alterations in heart rate. Both changes are proarrhythmic and contribute to arrhythmia recurrence. In spite of the clinical, pathologic, and economic importance of AF, many questions remain about its management." @default.
- W1997766734 created "2016-06-24" @default.
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- W1997766734 date "2005-09-01" @default.
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- W1997766734 title "Normal sinus rhythm without the normal atrial kick" @default.
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- W1997766734 doi "https://doi.org/10.1016/j.hrthm.2005.07.002" @default.
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