FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997768642> ?p ?o ?g. }

• W1997768642 abstract "Women under hormone replacement therapy carry an increased risk of venous thromboembolism (VTE), mostly during the first year. Despite great efforts devoted to hormone therapy research, VTE remains a major drawback of estrogenic therapy, and the search for new compounds continues. We have synthesized and evaluated prolame, an aminoestrogen with anticoagulant properties. The aim of our work was to elucidate the anticoagulant mechanism of prolame.We studied the effects of prolame on nitric oxide (NO) synthesis in cultured endothelial cells and platelets using flow cytometry, on NO metabolites using a modified Griess method, on NO formation in vivo using electron paramagnetic resonance spectroscopy, on participation of nuclear estrogen receptors using flow cytometry, and on endothelial NO synthase (eNOS) mRNA expression using RT-PCR. We also studied the impact of prolame-treated endothelial cells (EC) on ADP-induced platelet aggregation, as well as the ability to prevent occlusive thrombi in an in vivo mice thrombosis model.(a) Prolame induces NO production in ECs, platelets, and in a mouse model in vivo. (b) The NO-elevating effect of prolame can only be partially attributed to the nuclear estrogen receptors (ERs) since endothelial nitric oxide synthase (e-NOS) is slightly induced (37%) in ECs treated with prolame. (c) Platelets become 60% less responsive to aggregation induced by 10muM ADP when in suspension with prolame-treated ECs. (d) Prolame reduces the formation of thrombi in an in vivo thrombosis model.Prolame could be a preferred alternative to other estrogens because of its reduced thromboembolic risk." @default.
• W1997768642 created "2016-06-24" @default.
• W1997768642 creator A5020767501 @default.
• W1997768642 creator A5021288954 @default.
• W1997768642 creator A5031819044 @default.
• W1997768642 creator A5034550378 @default.
• W1997768642 creator A5035153896 @default.
• W1997768642 creator A5041153270 @default.
• W1997768642 creator A5048680840 @default.
• W1997768642 creator A5065772281 @default.
• W1997768642 creator A5067901602 @default.
• W1997768642 creator A5073697566 @default.
• W1997768642 creator A5077159822 @default.
• W1997768642 creator A5089267232 @default.
• W1997768642 date "2010-01-01" @default.
• W1997768642 modified "2023-10-17" @default.
• W1997768642 title "The antithrombotic effect of the aminoestrogen prolame (N-(3-hydroxy-1,3,5(10)-estratrien-17B-YL)-3-hydroxypropylamine) is linked to an increase in nitric oxide production by platelets and endothelial cells" @default.
• W1997768642 cites W101862950 @default.
• W1997768642 cites W1586699954 @default.
• W1997768642 cites W1919507270 @default.
• W1997768642 cites W1976982281 @default.
• W1997768642 cites W1998048586 @default.
• W1997768642 cites W2002300047 @default.
• W1997768642 cites W2003640964 @default.
• W1997768642 cites W2012633834 @default.
• W1997768642 cites W2017779206 @default.
• W1997768642 cites W2019468623 @default.
• W1997768642 cites W2024385537 @default.
• W1997768642 cites W2028695970 @default.
• W1997768642 cites W2034825883 @default.
• W1997768642 cites W2035067553 @default.
• W1997768642 cites W2041493088 @default.
• W1997768642 cites W2050778627 @default.
• W1997768642 cites W2055524046 @default.
• W1997768642 cites W2067057392 @default.
• W1997768642 cites W2070660975 @default.
• W1997768642 cites W2072170367 @default.
• W1997768642 cites W2080895981 @default.
• W1997768642 cites W2087689650 @default.
• W1997768642 cites W2113264115 @default.
• W1997768642 cites W2137806288 @default.
• W1997768642 cites W2149700343 @default.
• W1997768642 cites W2163244217 @default.
• W1997768642 cites W2167686810 @default.
• W1997768642 cites W2332056249 @default.
• W1997768642 doi "https://doi.org/10.1016/j.atherosclerosis.2009.06.017" @default.
• W1997768642 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19615684" @default.
• W1997768642 hasPublicationYear "2010" @default.
• W1997768642 type Work @default.
• W1997768642 sameAs 1997768642 @default.
• W1997768642 citedByCount "16" @default.
• W1997768642 countsByYear W19977686422012 @default.
• W1997768642 countsByYear W19977686422013 @default.
• W1997768642 countsByYear W19977686422015 @default.
• W1997768642 countsByYear W19977686422016 @default.
• W1997768642 countsByYear W19977686422017 @default.
• W1997768642 countsByYear W19977686422019 @default.
• W1997768642 countsByYear W19977686422020 @default.
• W1997768642 countsByYear W19977686422021 @default.
• W1997768642 crossrefType "journal-article" @default.
• W1997768642 hasAuthorship W1997768642A5020767501 @default.
• W1997768642 hasAuthorship W1997768642A5021288954 @default.
• W1997768642 hasAuthorship W1997768642A5031819044 @default.
• W1997768642 hasAuthorship W1997768642A5034550378 @default.
• W1997768642 hasAuthorship W1997768642A5035153896 @default.
• W1997768642 hasAuthorship W1997768642A5041153270 @default.
• W1997768642 hasAuthorship W1997768642A5048680840 @default.
• W1997768642 hasAuthorship W1997768642A5065772281 @default.
• W1997768642 hasAuthorship W1997768642A5067901602 @default.
• W1997768642 hasAuthorship W1997768642A5073697566 @default.
• W1997768642 hasAuthorship W1997768642A5077159822 @default.
• W1997768642 hasAuthorship W1997768642A5089267232 @default.
• W1997768642 hasConcept C121608353 @default.
• W1997768642 hasConcept C126322002 @default.
• W1997768642 hasConcept C150903083 @default.
• W1997768642 hasConcept C185592680 @default.
• W1997768642 hasConcept C203014093 @default.
• W1997768642 hasConcept C207001950 @default.
• W1997768642 hasConcept C2777015399 @default.
• W1997768642 hasConcept C2777622882 @default.
• W1997768642 hasConcept C2778326061 @default.
• W1997768642 hasConcept C519581460 @default.
• W1997768642 hasConcept C530470458 @default.
• W1997768642 hasConcept C553184892 @default.
• W1997768642 hasConcept C71924100 @default.
• W1997768642 hasConcept C84606932 @default.
• W1997768642 hasConcept C86803240 @default.
• W1997768642 hasConcept C89560881 @default.
• W1997768642 hasConcept C98274493 @default.
• W1997768642 hasConceptScore W1997768642C121608353 @default.
• W1997768642 hasConceptScore W1997768642C126322002 @default.
• W1997768642 hasConceptScore W1997768642C150903083 @default.
• W1997768642 hasConceptScore W1997768642C185592680 @default.
• W1997768642 hasConceptScore W1997768642C203014093 @default.
• W1997768642 hasConceptScore W1997768642C207001950 @default.
• W1997768642 hasConceptScore W1997768642C2777015399 @default.
• W1997768642 hasConceptScore W1997768642C2777622882 @default.
• W1997768642 hasConceptScore W1997768642C2778326061 @default.
• W1997768642 hasConceptScore W1997768642C519581460 @default.
• W1997768642 hasConceptScore W1997768642C530470458 @default.

• next