FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997773608> ?p ?o ?g. }

• W1997773608 abstract "Post-transcriptional gene regulation is robustly regulated by RNA-binding proteins (RBPs). Here we describe the collection of RNAs regulated by AUF1 (AU-binding factor 1), an RBP linked to cancer, inflammation and aging. Photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation (PAR-CLIP) analysis reveals that AUF1 primarily recognizes U-/GU-rich sequences in mRNAs and noncoding RNAs and influences target transcript fate in three main directions. First, AUF1 lowers the steady-state levels of numerous target RNAs, including long noncoding RNA NEAT1, in turn affecting the organization of nuclear paraspeckles. Second, AUF1 does not change the abundance of many target RNAs, but ribosome profiling reveals that AUF1 promotes the translation of numerous mRNAs in this group. Third, AUF1 unexpectedly enhances the steady-state levels of several target mRNAs encoding DNA-maintenance proteins. Through its actions on target RNAs, AUF1 preserves genomic integrity, in agreement with the AUF1-elicited prevention of premature cellular senescence. AUF1 is an RNA-binding protein believed to function mostly by regulating the decay of its target transcripts. Here, Yoon et al.systematically identify the targets of AUF1 and provide insights into how AUF1 functions to regulate various cellular processes by enhancing the decay, stability or translation of specific RNAs." @default.
• W1997773608 created "2016-06-24" @default.
• W1997773608 creator A5006152899 @default.
• W1997773608 creator A5006990099 @default.
• W1997773608 creator A5013145287 @default.
• W1997773608 creator A5016282453 @default.
• W1997773608 creator A5022033169 @default.
• W1997773608 creator A5027878787 @default.
• W1997773608 creator A5029162817 @default.
• W1997773608 creator A5033469228 @default.
• W1997773608 creator A5035382399 @default.
• W1997773608 creator A5040179399 @default.
• W1997773608 creator A5041792310 @default.
• W1997773608 creator A5042084987 @default.
• W1997773608 creator A5044404083 @default.
• W1997773608 creator A5045390774 @default.
• W1997773608 creator A5050925099 @default.
• W1997773608 creator A5052081713 @default.
• W1997773608 creator A5055645967 @default.
• W1997773608 creator A5062087832 @default.
• W1997773608 creator A5062269074 @default.
• W1997773608 creator A5063625487 @default.
• W1997773608 creator A5064301050 @default.
• W1997773608 creator A5073039727 @default.
• W1997773608 creator A5079833018 @default.
• W1997773608 date "2014-11-04" @default.
• W1997773608 modified "2023-10-16" @default.
• W1997773608 title "PAR-CLIP analysis uncovers AUF1 impact on target RNA fate and genome integrity" @default.
• W1997773608 cites W1608607554 @default.
• W1997773608 cites W1964113455 @default.
• W1997773608 cites W1986521568 @default.
• W1997773608 cites W1986624221 @default.
• W1997773608 cites W1989504358 @default.
• W1997773608 cites W2006547663 @default.
• W1997773608 cites W2008374869 @default.
• W1997773608 cites W2010081999 @default.
• W1997773608 cites W2011107125 @default.
• W1997773608 cites W2012468371 @default.
• W1997773608 cites W2013566223 @default.
• W1997773608 cites W2019009111 @default.
• W1997773608 cites W2019047197 @default.
• W1997773608 cites W2022572059 @default.
• W1997773608 cites W2025728827 @default.
• W1997773608 cites W2039816251 @default.
• W1997773608 cites W2051282896 @default.
• W1997773608 cites W2052969704 @default.
• W1997773608 cites W2053003053 @default.
• W1997773608 cites W2058659458 @default.
• W1997773608 cites W2058970225 @default.
• W1997773608 cites W2059646461 @default.
• W1997773608 cites W2064492560 @default.
• W1997773608 cites W2070780623 @default.
• W1997773608 cites W2071849521 @default.
• W1997773608 cites W2072910036 @default.
• W1997773608 cites W2082102894 @default.
• W1997773608 cites W2085555782 @default.
• W1997773608 cites W2086157203 @default.
• W1997773608 cites W2087179902 @default.
• W1997773608 cites W2087299162 @default.
• W1997773608 cites W2087528029 @default.
• W1997773608 cites W2105353448 @default.
• W1997773608 cites W2111841684 @default.
• W1997773608 cites W2113576489 @default.
• W1997773608 cites W2124224077 @default.
• W1997773608 cites W2127337265 @default.
• W1997773608 cites W2128688272 @default.
• W1997773608 cites W2129216514 @default.
• W1997773608 cites W2131445177 @default.
• W1997773608 cites W2133142263 @default.
• W1997773608 cites W2138413381 @default.
• W1997773608 cites W2139210450 @default.
• W1997773608 cites W2139911809 @default.
• W1997773608 cites W2152432732 @default.
• W1997773608 cites W2156205933 @default.
• W1997773608 cites W2157277499 @default.
• W1997773608 cites W2159376549 @default.
• W1997773608 cites W2159934528 @default.
• W1997773608 cites W2160938780 @default.
• W1997773608 cites W2163106706 @default.
• W1997773608 cites W2163482854 @default.
• W1997773608 cites W2164451932 @default.
• W1997773608 cites W2165169748 @default.
• W1997773608 cites W4243574300 @default.
• W1997773608 doi "https://doi.org/10.1038/ncomms6248" @default.
• W1997773608 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4291169" @default.
• W1997773608 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25366541" @default.
• W1997773608 hasPublicationYear "2014" @default.
• W1997773608 type Work @default.
• W1997773608 sameAs 1997773608 @default.
• W1997773608 citedByCount "135" @default.
• W1997773608 countsByYear W19977736082015 @default.
• W1997773608 countsByYear W19977736082016 @default.
• W1997773608 countsByYear W19977736082017 @default.
• W1997773608 countsByYear W19977736082018 @default.
• W1997773608 countsByYear W19977736082019 @default.
• W1997773608 countsByYear W19977736082020 @default.
• W1997773608 countsByYear W19977736082021 @default.
• W1997773608 countsByYear W19977736082022 @default.
• W1997773608 countsByYear W19977736082023 @default.
• W1997773608 crossrefType "journal-article" @default.

• next