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- W1997783558 endingPage "802" @default.
- W1997783558 startingPage "794" @default.
- W1997783558 abstract "A number of transport mechanisms in the colonic epithelium contribute to HCO3− movement across the apical and basolateral membranes, but this ion has been largely regarded as a by-product of the transport functions it is involved in, such as NaCl- or short chain fatty acid (SCFA) absorption. However, emerging data points to several specific roles of HCO3− for colonic epithelial physiology, including pH control in the colonic surface microenvironment, which is important for transport- and immune functions, as well as the secretion and the rheological properties of the mucus gel. Furthermore, recent studies have demonstrated that colonic HCO3− transporters are expressed in a highly segmental as well as species-specific manner. This review summarizes recently gathered information on the functional anatomy of the colon, the roles of HCO3− in the colonic epithelium, colonic mucosal integrity, and the expression and function of HCO3− transporting mechanisms in health and disease." @default.
- W1997783558 created "2016-06-24" @default.
- W1997783558 creator A5024119946 @default.
- W1997783558 creator A5070186988 @default.
- W1997783558 date "2011-01-01" @default.
- W1997783558 modified "2023-10-14" @default.
- W1997783558 title "News from the End of the Gut-How the Highly Segmental Pattern of Colonic HCO3- Transport Relates to Absorptive Function and Mucosal Integrity" @default.
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