FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997788236> ?p ?o ?g. }

• W1997788236 endingPage "636" @default.
• W1997788236 startingPage "630" @default.
• W1997788236 abstract "Background The prognosis and management of incidental perineural invasion (PNI) in patients with cutaneous squamous cell carcinoma (CSCC) has not been well defined. Objective We sought to investigate the clinical, histologic, and treatment characteristics associated with incidental PNI, histologic PNI extending beyond the tumor bulk, in patients with CSCC. Methods We conducted a multicenter prospective analysis of patients with CSCC undergoing Mohs micrographic surgery. Results The incidence of PNI was 4.6% in 753 CSCC cases. PNI was significantly associated with tumors of the head and neck (P = .039), larger tumor diameter (P < .001), presence of clinically palpable lymphadenopathy (P = .012), and recurrent (P < .001) and painful (P < .001) tumors. Further, PNI was significantly associated with poor tumor differentiation (P < .001), greater tumor thickness (P < .001), a greater number of Mohs stages (P < .001), and larger estimated maximum Mohs margin (P < .001) required to clear the tumor. Limitations The low numbers of patients demonstrating incidental PNI limits this study. Conclusions The association of incidental PNI with clinicopathological indicators of poor prognosis suggests that incidental PNI may serve as a marker to improve the precision in the prognostic assessment of patients with CSCC. The prognosis and management of incidental perineural invasion (PNI) in patients with cutaneous squamous cell carcinoma (CSCC) has not been well defined. We sought to investigate the clinical, histologic, and treatment characteristics associated with incidental PNI, histologic PNI extending beyond the tumor bulk, in patients with CSCC. We conducted a multicenter prospective analysis of patients with CSCC undergoing Mohs micrographic surgery. The incidence of PNI was 4.6% in 753 CSCC cases. PNI was significantly associated with tumors of the head and neck (P = .039), larger tumor diameter (P < .001), presence of clinically palpable lymphadenopathy (P = .012), and recurrent (P < .001) and painful (P < .001) tumors. Further, PNI was significantly associated with poor tumor differentiation (P < .001), greater tumor thickness (P < .001), a greater number of Mohs stages (P < .001), and larger estimated maximum Mohs margin (P < .001) required to clear the tumor. The low numbers of patients demonstrating incidental PNI limits this study. The association of incidental PNI with clinicopathological indicators of poor prognosis suggests that incidental PNI may serve as a marker to improve the precision in the prognostic assessment of patients with CSCC." @default.
• W1997788236 created "2016-06-24" @default.
• W1997788236 creator A5036016406 @default.
• W1997788236 creator A5049472913 @default.
• W1997788236 creator A5064249197 @default.
• W1997788236 date "2014-04-01" @default.
• W1997788236 modified "2023-10-11" @default.
• W1997788236 title "A prospective evaluation of the clinical, histologic, and therapeutic variables associated with incidental perineural invasion in cutaneous squamous cell carcinoma" @default.
• W1997788236 cites W1484984825 @default.
• W1997788236 cites W1594237846 @default.
• W1997788236 cites W1857531999 @default.
• W1997788236 cites W1964154174 @default.
• W1997788236 cites W1966603644 @default.
• W1997788236 cites W1978486444 @default.
• W1997788236 cites W1987049028 @default.
• W1997788236 cites W1995272236 @default.
• W1997788236 cites W2006519119 @default.
• W1997788236 cites W2018404789 @default.
• W1997788236 cites W2034670381 @default.
• W1997788236 cites W2039716328 @default.
• W1997788236 cites W2041972418 @default.
• W1997788236 cites W2043613911 @default.
• W1997788236 cites W2048636698 @default.
• W1997788236 cites W2057388449 @default.
• W1997788236 cites W2067585098 @default.
• W1997788236 cites W2067597233 @default.
• W1997788236 cites W2073675722 @default.
• W1997788236 cites W2074254324 @default.
• W1997788236 cites W2078159813 @default.
• W1997788236 cites W2086238536 @default.
• W1997788236 cites W2089933604 @default.
• W1997788236 cites W2098423823 @default.
• W1997788236 cites W2119358637 @default.
• W1997788236 cites W2144799273 @default.
• W1997788236 cites W2146086092 @default.
• W1997788236 cites W2163190748 @default.
• W1997788236 cites W47220314 @default.
• W1997788236 doi "https://doi.org/10.1016/j.jaad.2013.11.034" @default.
• W1997788236 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24433872" @default.
• W1997788236 hasPublicationYear "2014" @default.
• W1997788236 type Work @default.
• W1997788236 sameAs 1997788236 @default.
• W1997788236 citedByCount "48" @default.
• W1997788236 countsByYear W19977882362014 @default.
• W1997788236 countsByYear W19977882362015 @default.
• W1997788236 countsByYear W19977882362016 @default.
• W1997788236 countsByYear W19977882362017 @default.
• W1997788236 countsByYear W19977882362018 @default.
• W1997788236 countsByYear W19977882362019 @default.
• W1997788236 countsByYear W19977882362020 @default.
• W1997788236 countsByYear W19977882362021 @default.
• W1997788236 countsByYear W19977882362022 @default.
• W1997788236 countsByYear W19977882362023 @default.
• W1997788236 crossrefType "journal-article" @default.
• W1997788236 hasAuthorship W1997788236A5036016406 @default.
• W1997788236 hasAuthorship W1997788236A5049472913 @default.
• W1997788236 hasAuthorship W1997788236A5064249197 @default.
• W1997788236 hasConcept C120665830 @default.
• W1997788236 hasConcept C121332964 @default.
• W1997788236 hasConcept C121608353 @default.
• W1997788236 hasConcept C126322002 @default.
• W1997788236 hasConcept C126838900 @default.
• W1997788236 hasConcept C142724271 @default.
• W1997788236 hasConcept C143998085 @default.
• W1997788236 hasConcept C188816634 @default.
• W1997788236 hasConcept C2777154038 @default.
• W1997788236 hasConcept C2777546739 @default.
• W1997788236 hasConcept C2778334829 @default.
• W1997788236 hasConcept C3019992690 @default.
• W1997788236 hasConcept C61511704 @default.
• W1997788236 hasConcept C71924100 @default.
• W1997788236 hasConceptScore W1997788236C120665830 @default.
• W1997788236 hasConceptScore W1997788236C121332964 @default.
• W1997788236 hasConceptScore W1997788236C121608353 @default.
• W1997788236 hasConceptScore W1997788236C126322002 @default.
• W1997788236 hasConceptScore W1997788236C126838900 @default.
• W1997788236 hasConceptScore W1997788236C142724271 @default.
• W1997788236 hasConceptScore W1997788236C143998085 @default.
• W1997788236 hasConceptScore W1997788236C188816634 @default.
• W1997788236 hasConceptScore W1997788236C2777154038 @default.
• W1997788236 hasConceptScore W1997788236C2777546739 @default.
• W1997788236 hasConceptScore W1997788236C2778334829 @default.
• W1997788236 hasConceptScore W1997788236C3019992690 @default.
• W1997788236 hasConceptScore W1997788236C61511704 @default.
• W1997788236 hasConceptScore W1997788236C71924100 @default.
• W1997788236 hasIssue "4" @default.
• W1997788236 hasLocation W19977882361 @default.
• W1997788236 hasLocation W19977882362 @default.
• W1997788236 hasOpenAccess W1997788236 @default.
• W1997788236 hasPrimaryLocation W19977882361 @default.
• W1997788236 hasRelatedWork W1979070461 @default.
• W1997788236 hasRelatedWork W2017194589 @default.
• W1997788236 hasRelatedWork W2034018073 @default.
• W1997788236 hasRelatedWork W2163190748 @default.
• W1997788236 hasRelatedWork W2735775692 @default.
• W1997788236 hasRelatedWork W2794191114 @default.
• W1997788236 hasRelatedWork W2905690324 @default.
• W1997788236 hasRelatedWork W3024050243 @default.

• next