Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997797784> ?p ?o ?g. }
- W1997797784 endingPage "126" @default.
- W1997797784 startingPage "119" @default.
- W1997797784 abstract "Brain-derived neurotrophic factor (BDNF) plays an essential role in neuronal survival, proliferation, and synaptic remodeling and modulates the function of many other neurotransmitters. Additionally, it likely underlies neurodegenerative and psychiatric disorders, including alcohol dependence-related depression (AD-D). Here, we investigated the possible association between three single nucleotide polymorphisms (SNPs) of the BDNF gene (rs13306221, rs6265, rs16917204) and AD-D. Of 548 patients with alcohol dependence (AD), 166 had AD-D and 312 healthy controls. Response to 8-week sertraline treatment was also assessed. The frequency of the A allele of rs6265 (Val66Met) was significantly higher in AD-D patients than in the healthy controls (p=0.009 after Bonferroni correction). The analysis revealed a strong association between the rs6265 genotype distribution and AD-D (p=0.005 after Bonferroni correction), and the A allele of rs6265 was significantly overrepresented in AD-D patients compared to AD without depression (AD-nD) patients (p=0.001 after Bonferroni correction). Additionally, carriers of the A allele of rs6265 responded better to sertraline treatment (p=0.001). Our results suggested a novel association between BDNF rs6265 and AD-D. These findings might lead to earlier detection of AD-D, perhaps providing better tools for clinical care of these patients in the future." @default.
- W1997797784 created "2016-06-24" @default.
- W1997797784 creator A5022733166 @default.
- W1997797784 creator A5024224931 @default.
- W1997797784 creator A5026104277 @default.
- W1997797784 creator A5027548441 @default.
- W1997797784 creator A5032095782 @default.
- W1997797784 creator A5035548369 @default.
- W1997797784 creator A5039591590 @default.
- W1997797784 creator A5042927878 @default.
- W1997797784 creator A5053607387 @default.
- W1997797784 creator A5057523516 @default.
- W1997797784 creator A5066829275 @default.
- W1997797784 creator A5066990241 @default.
- W1997797784 creator A5073209400 @default.
- W1997797784 creator A5082316592 @default.
- W1997797784 date "2011-09-01" @default.
- W1997797784 modified "2023-09-25" @default.
- W1997797784 title "The brain-derived neurotrophic factor is associated with alcohol dependence-related depression and antidepressant response" @default.
- W1997797784 cites W1603180106 @default.
- W1997797784 cites W1968488639 @default.
- W1997797784 cites W1976844070 @default.
- W1997797784 cites W1980437773 @default.
- W1997797784 cites W1980719669 @default.
- W1997797784 cites W1982185635 @default.
- W1997797784 cites W1984388818 @default.
- W1997797784 cites W1987309900 @default.
- W1997797784 cites W1990482736 @default.
- W1997797784 cites W1993293620 @default.
- W1997797784 cites W1995556701 @default.
- W1997797784 cites W1997906961 @default.
- W1997797784 cites W2000455803 @default.
- W1997797784 cites W2007156391 @default.
- W1997797784 cites W2013373204 @default.
- W1997797784 cites W2015250725 @default.
- W1997797784 cites W2018815299 @default.
- W1997797784 cites W2019304428 @default.
- W1997797784 cites W2029278453 @default.
- W1997797784 cites W2037383099 @default.
- W1997797784 cites W2038523539 @default.
- W1997797784 cites W2053578577 @default.
- W1997797784 cites W2056591616 @default.
- W1997797784 cites W2058640434 @default.
- W1997797784 cites W2058704610 @default.
- W1997797784 cites W2061088962 @default.
- W1997797784 cites W2062427015 @default.
- W1997797784 cites W2063839886 @default.
- W1997797784 cites W2069858792 @default.
- W1997797784 cites W2071660247 @default.
- W1997797784 cites W2079527591 @default.
- W1997797784 cites W2084760086 @default.
- W1997797784 cites W2084828933 @default.
- W1997797784 cites W2087404902 @default.
- W1997797784 cites W2088939203 @default.
- W1997797784 cites W2091398960 @default.
- W1997797784 cites W2093567002 @default.
- W1997797784 cites W2103606283 @default.
- W1997797784 cites W2112871310 @default.
- W1997797784 cites W2123213273 @default.
- W1997797784 cites W2123475692 @default.
- W1997797784 cites W2130417276 @default.
- W1997797784 cites W2135077917 @default.
- W1997797784 cites W2139984345 @default.
- W1997797784 cites W2147773916 @default.
- W1997797784 cites W2155345881 @default.
- W1997797784 cites W2159123213 @default.
- W1997797784 cites W2159950826 @default.
- W1997797784 cites W2160589013 @default.
- W1997797784 cites W2163936607 @default.
- W1997797784 cites W2164761760 @default.
- W1997797784 cites W2165212639 @default.
- W1997797784 cites W2170633473 @default.
- W1997797784 cites W2171321056 @default.
- W1997797784 cites W2252948336 @default.
- W1997797784 cites W2274004823 @default.
- W1997797784 cites W2323436072 @default.
- W1997797784 cites W2404639217 @default.
- W1997797784 cites W4294307687 @default.
- W1997797784 doi "https://doi.org/10.1016/j.brainres.2011.08.005" @default.
- W1997797784 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21880305" @default.
- W1997797784 hasPublicationYear "2011" @default.
- W1997797784 type Work @default.
- W1997797784 sameAs 1997797784 @default.
- W1997797784 citedByCount "37" @default.
- W1997797784 countsByYear W19977977842012 @default.
- W1997797784 countsByYear W19977977842013 @default.
- W1997797784 countsByYear W19977977842014 @default.
- W1997797784 countsByYear W19977977842015 @default.
- W1997797784 countsByYear W19977977842016 @default.
- W1997797784 countsByYear W19977977842017 @default.
- W1997797784 countsByYear W19977977842018 @default.
- W1997797784 countsByYear W19977977842019 @default.
- W1997797784 countsByYear W19977977842021 @default.
- W1997797784 countsByYear W19977977842022 @default.
- W1997797784 countsByYear W19977977842023 @default.
- W1997797784 crossrefType "journal-article" @default.
- W1997797784 hasAuthorship W1997797784A5022733166 @default.
- W1997797784 hasAuthorship W1997797784A5024224931 @default.