FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997799199> ?p ?o ?g. }

• W1997799199 endingPage "1767" @default.
• W1997799199 startingPage "1763" @default.
• W1997799199 abstract "In vivo synthesis of peptides by bacterial expression has developed into a reliable alternative to solid-phase peptide synthesis. A significant drawback of in vivo methods is the difficulty with which gene products can be modified post-translationally. Here, we present a method for the facile modification of peptides generated in bacterial hosts after cyanogen bromide cleavage at C-terminal methionines. Reaction of the resulting homoserine lactones with propargylamine allows efficient and selective modification with a wide variety of chemicals such as fluorescent dyes, biotin derivatives, polyprenyls, lipids, polysaccharides, or peptides. Attachment of the cell penetrating peptide octa-arginine (R8) to peptides derived from the proapoptotic tumor suppressor Bak BH3 led to efficient cellular uptake and subsequent cytochrome c release from mitochondria, culminating in induction of apoptosis similar to that observed with peptides linked to R8 via the peptide backbone. These results highlight the significant potential for use of such tools in live cells." @default.
• W1997799199 created "2016-06-24" @default.
• W1997799199 creator A5005574048 @default.
• W1997799199 creator A5010097977 @default.
• W1997799199 creator A5011146439 @default.
• W1997799199 creator A5024864543 @default.
• W1997799199 creator A5026275344 @default.
• W1997799199 creator A5050585535 @default.
• W1997799199 creator A5064184281 @default.
• W1997799199 creator A5078364665 @default.
• W1997799199 date "2011-08-15" @default.
• W1997799199 modified "2023-09-23" @default.
• W1997799199 title "Chemical Synthesis of Cell-Permeable Apoptotic Peptides from <i>in Vivo</i> Produced Proteins" @default.
• W1997799199 cites W1964307492 @default.
• W1997799199 cites W1965467605 @default.
• W1997799199 cites W1976223354 @default.
• W1997799199 cites W1978344336 @default.
• W1997799199 cites W1980837484 @default.
• W1997799199 cites W1984694269 @default.
• W1997799199 cites W1987349623 @default.
• W1997799199 cites W1990497503 @default.
• W1997799199 cites W1992947288 @default.
• W1997799199 cites W1993125234 @default.
• W1997799199 cites W1999253307 @default.
• W1997799199 cites W2001585691 @default.
• W1997799199 cites W2004421590 @default.
• W1997799199 cites W2014171031 @default.
• W1997799199 cites W2015588963 @default.
• W1997799199 cites W2035335770 @default.
• W1997799199 cites W2050000500 @default.
• W1997799199 cites W2050907146 @default.
• W1997799199 cites W2076859770 @default.
• W1997799199 cites W2079335891 @default.
• W1997799199 cites W2081016100 @default.
• W1997799199 cites W2083238386 @default.
• W1997799199 cites W2085948054 @default.
• W1997799199 cites W2088187860 @default.
• W1997799199 cites W2094520392 @default.
• W1997799199 cites W2097137007 @default.
• W1997799199 cites W2097933346 @default.
• W1997799199 cites W2106799894 @default.
• W1997799199 cites W2123650819 @default.
• W1997799199 cites W2124523818 @default.
• W1997799199 cites W2125488622 @default.
• W1997799199 cites W2145575227 @default.
• W1997799199 cites W2145642736 @default.
• W1997799199 cites W2150048195 @default.
• W1997799199 cites W2156379460 @default.
• W1997799199 cites W2168632005 @default.
• W1997799199 cites W2208136208 @default.
• W1997799199 cites W2334665661 @default.
• W1997799199 cites W3149236675 @default.
• W1997799199 cites W4256503849 @default.
• W1997799199 doi "https://doi.org/10.1021/bc200338u" @default.
• W1997799199 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21823633" @default.
• W1997799199 hasPublicationYear "2011" @default.
• W1997799199 type Work @default.
• W1997799199 sameAs 1997799199 @default.
• W1997799199 citedByCount "6" @default.
• W1997799199 countsByYear W19977991992012 @default.
• W1997799199 countsByYear W19977991992015 @default.
• W1997799199 countsByYear W19977991992016 @default.
• W1997799199 countsByYear W19977991992019 @default.
• W1997799199 crossrefType "journal-article" @default.
• W1997799199 hasAuthorship W1997799199A5005574048 @default.
• W1997799199 hasAuthorship W1997799199A5010097977 @default.
• W1997799199 hasAuthorship W1997799199A5011146439 @default.
• W1997799199 hasAuthorship W1997799199A5024864543 @default.
• W1997799199 hasAuthorship W1997799199A5026275344 @default.
• W1997799199 hasAuthorship W1997799199A5050585535 @default.
• W1997799199 hasAuthorship W1997799199A5064184281 @default.
• W1997799199 hasAuthorship W1997799199A5078364665 @default.
• W1997799199 hasConcept C104317684 @default.
• W1997799199 hasConcept C127413603 @default.
• W1997799199 hasConcept C1491633281 @default.
• W1997799199 hasConcept C150903083 @default.
• W1997799199 hasConcept C167625842 @default.
• W1997799199 hasConcept C175156509 @default.
• W1997799199 hasConcept C185592680 @default.
• W1997799199 hasConcept C187320778 @default.
• W1997799199 hasConcept C190283241 @default.
• W1997799199 hasConcept C202751555 @default.
• W1997799199 hasConcept C207001950 @default.
• W1997799199 hasConcept C2777093645 @default.
• W1997799199 hasConcept C2779281246 @default.
• W1997799199 hasConcept C29311851 @default.
• W1997799199 hasConcept C43369102 @default.
• W1997799199 hasConcept C55493867 @default.
• W1997799199 hasConcept C86803240 @default.
• W1997799199 hasConceptScore W1997799199C104317684 @default.
• W1997799199 hasConceptScore W1997799199C127413603 @default.
• W1997799199 hasConceptScore W1997799199C1491633281 @default.
• W1997799199 hasConceptScore W1997799199C150903083 @default.
• W1997799199 hasConceptScore W1997799199C167625842 @default.
• W1997799199 hasConceptScore W1997799199C175156509 @default.
• W1997799199 hasConceptScore W1997799199C185592680 @default.
• W1997799199 hasConceptScore W1997799199C187320778 @default.
• W1997799199 hasConceptScore W1997799199C190283241 @default.

• next