Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997804537> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W1997804537 abstract "Two chemically related arylazido photoaffinity analogs of ATP (arylazido aminopropionyl ATP (ANAPP3) and arylazido aminobutyryl ATP (ANABP3)), which have been reported in the literature to differ in their ability to inhibit myosin ATPase, were compared for their ability to antagonize contractile responses of the isolated guinea-pig vas deferens to ATP. During photolysis in organ chambers the photoconversion (delta A260/delta t) of ANAPP3 occurred with greater than first order kinetics or was multiexponential and t1/2 = 7.5 min, while delta A260/delta t for ANABP3 was first order and t1/2 = 2.25 min. After photolysis of these compounds in the presence of the guinea-pig vas deferens, using irradiation periods which caused 80% consumption of the compounds, ANABP3 was 2-3 times more potent than ANAPP3 in antagonizing contractions to ATP, which are mediated by P2-purinergic receptors. A comparison of concentration-response curves obtained for nonphotolyzed ANAPP3 and ANABP3 used as agonists suggested that the greater antagonism produced by photolyzed ANABP3 is not attributable to a greater potency. The results suggest that the longer 3'-hydroxyl-arylazide bridge length of ANABP3 places the arylnitrene intermediate in a position at or near the P2-receptor which is more favorable for covalent insertion." @default.
- W1997804537 created "2016-06-24" @default.
- W1997804537 creator A5034388597 @default.
- W1997804537 creator A5050599439 @default.
- W1997804537 creator A5064269241 @default.
- W1997804537 date "1983-01-01" @default.
- W1997804537 modified "2023-09-27" @default.
- W1997804537 title "Comparison of photoaffinity labeling og P2-purinergic receptors of isolated guinea-pig vas deferens by arylazido aminopropionyl ATP and by arylazido aminobutyryl ATP" @default.
- W1997804537 cites W1991704335 @default.
- W1997804537 cites W2006052083 @default.
- W1997804537 cites W2009523077 @default.
- W1997804537 cites W2041265702 @default.
- W1997804537 cites W2065498340 @default.
- W1997804537 cites W2107449157 @default.
- W1997804537 cites W65273243 @default.
- W1997804537 doi "https://doi.org/10.1016/0014-2999(83)90193-0" @default.
- W1997804537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6299761" @default.
- W1997804537 hasPublicationYear "1983" @default.
- W1997804537 type Work @default.
- W1997804537 sameAs 1997804537 @default.
- W1997804537 citedByCount "9" @default.
- W1997804537 crossrefType "journal-article" @default.
- W1997804537 hasAuthorship W1997804537A5034388597 @default.
- W1997804537 hasAuthorship W1997804537A5050599439 @default.
- W1997804537 hasAuthorship W1997804537A5064269241 @default.
- W1997804537 hasConcept C12554922 @default.
- W1997804537 hasConcept C134018914 @default.
- W1997804537 hasConcept C170493617 @default.
- W1997804537 hasConcept C185592680 @default.
- W1997804537 hasConcept C2778210472 @default.
- W1997804537 hasConcept C2778581200 @default.
- W1997804537 hasConcept C2778815084 @default.
- W1997804537 hasConcept C55493867 @default.
- W1997804537 hasConcept C57306754 @default.
- W1997804537 hasConcept C86803240 @default.
- W1997804537 hasConceptScore W1997804537C12554922 @default.
- W1997804537 hasConceptScore W1997804537C134018914 @default.
- W1997804537 hasConceptScore W1997804537C170493617 @default.
- W1997804537 hasConceptScore W1997804537C185592680 @default.
- W1997804537 hasConceptScore W1997804537C2778210472 @default.
- W1997804537 hasConceptScore W1997804537C2778581200 @default.
- W1997804537 hasConceptScore W1997804537C2778815084 @default.
- W1997804537 hasConceptScore W1997804537C55493867 @default.
- W1997804537 hasConceptScore W1997804537C57306754 @default.
- W1997804537 hasConceptScore W1997804537C86803240 @default.
- W1997804537 hasLocation W19978045371 @default.
- W1997804537 hasLocation W19978045372 @default.
- W1997804537 hasOpenAccess W1997804537 @default.
- W1997804537 hasPrimaryLocation W19978045371 @default.
- W1997804537 hasRelatedWork W1969320473 @default.
- W1997804537 hasRelatedWork W1972345958 @default.
- W1997804537 hasRelatedWork W1990201766 @default.
- W1997804537 hasRelatedWork W1997804537 @default.
- W1997804537 hasRelatedWork W2028841585 @default.
- W1997804537 hasRelatedWork W2056620377 @default.
- W1997804537 hasRelatedWork W2062640955 @default.
- W1997804537 hasRelatedWork W2081118948 @default.
- W1997804537 hasRelatedWork W2889382689 @default.
- W1997804537 hasRelatedWork W3101962651 @default.
- W1997804537 isParatext "false" @default.
- W1997804537 isRetracted "false" @default.
- W1997804537 magId "1997804537" @default.
- W1997804537 workType "article" @default.