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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997806072> ?p ?o ?g. }

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• W1997806072 abstract "Like Cyclosporin A (CsA), the macrollde FK 506 is a potent immunosuppresslve that inhibits early steps of T cell activation, including the synthesis of Interleukin 2 (II-2) and numerous other lymphokines. The block of 11-2 synthesis occurs at the transcriptlonal level. At concentrations that block T cell activation, FK 506 and CsA inhibit the proto-enhancer activity of Purine boxes of the 11-2 promoter and the generation of lymphocyte-specific factors binding to the Purine boxes. Under the same conditions, the DNA binding of other 11-2 enhancer factors remains unaffected by both compounds. These results support the view that FK 506 and CsA, which both inhibit the activity of peptidylprolyl cls/trans isomerases, suppress T cell activation by a similar, if not identical mechanism." @default.
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• W1997806072 date "1991-01-01" @default.
• W1997806072 modified "2023-10-18" @default.
• W1997806072 title "The immunosuppressives FK 506 and cyclosporin A inhibit the generation of protein factors binding to the two purine boxes of the interleukin 2 enhancer" @default.
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• W1997806072 doi "https://doi.org/10.1093/nar/19.1.61" @default.
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