FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997806906> ?p ?o ?g. }

• W1997806906 endingPage "3148" @default.
• W1997806906 startingPage "3144" @default.
• W1997806906 abstract "We describe the results of an open label Phase I trial of a live attenuated H6N1 influenza virus vaccine (ClinicalTrials.gov Identifier: NCT00734175).We evaluated the safety, infectivity, and immunogenicity of two doses of 10(7) TCID(50) of the H6N1 Teal HK 97/AA ca vaccine, a cold-adapted and temperature sensitive live, attenuated influenza vaccine (LAIV) in healthy seronegative adults. Twenty-two participants received the first dose of the vaccine, and 18 received the second dose of vaccine 4 weeks later. The vaccine had a safety profile similar to that of other investigational LAIVs bearing avian hemagglutinin (HA) and neuraminidase (NA) genes. The vaccine was highly restricted in replication: two participants had virus detectable by rRT-PCR beyond day 1 after each dose. Antibody responses to the vaccine were also restricted: 43% of participants developed a serum antibody response as measured by any assay: 5% by hemagglutination-inhibition assay, 5% by microneutralization assay, 29% by ELISA for H6 HA-specific IgG and 24% by ELISA for H6 HA specific IgA after either 1 or 2 doses. Following the second dose, vaccine specific IgG and IgA secreting cells as measured by ELISPOT increased from a mean of 0.6 to 9.2/10(6) PBMCs and from 0.2 to 2.2/10(6) PBMCs, respectively.The H6N1 LAIV had a safety profile similar to that of LAIV bearing other HA and NA genes, but was highly restricted in replication in healthy seronegative adults. The H6N1 LAIV was also not as immunogenic as the seasonal LAIV." @default.
• W1997806906 created "2016-06-24" @default.
• W1997806906 creator A5010601658 @default.
• W1997806906 creator A5028974096 @default.
• W1997806906 creator A5036633698 @default.
• W1997806906 creator A5036869113 @default.
• W1997806906 creator A5043080193 @default.
• W1997806906 creator A5058850764 @default.
• W1997806906 creator A5059355135 @default.
• W1997806906 creator A5064066871 @default.
• W1997806906 creator A5073651161 @default.
• W1997806906 creator A5074126857 @default.
• W1997806906 creator A5075202938 @default.
• W1997806906 date "2011-04-01" @default.
• W1997806906 modified "2023-10-18" @default.
• W1997806906 title "An open label Phase I trial of a live attenuated H6N1 influenza virus vaccine in healthy adults" @default.
• W1997806906 cites W1886202267 @default.
• W1997806906 cites W1967362690 @default.
• W1997806906 cites W1971178088 @default.
• W1997806906 cites W1984534976 @default.
• W1997806906 cites W1990429464 @default.
• W1997806906 cites W1996396050 @default.
• W1997806906 cites W2009076229 @default.
• W1997806906 cites W2037859752 @default.
• W1997806906 cites W2051459836 @default.
• W1997806906 cites W2064091377 @default.
• W1997806906 cites W2076325072 @default.
• W1997806906 cites W2084063440 @default.
• W1997806906 cites W2097580384 @default.
• W1997806906 cites W2102104628 @default.
• W1997806906 cites W2109403777 @default.
• W1997806906 cites W2111818234 @default.
• W1997806906 cites W2121914008 @default.
• W1997806906 cites W2126309815 @default.
• W1997806906 cites W2139746780 @default.
• W1997806906 cites W2140249326 @default.
• W1997806906 cites W2148183046 @default.
• W1997806906 cites W2148734478 @default.
• W1997806906 cites W2154403354 @default.
• W1997806906 cites W2155467153 @default.
• W1997806906 cites W2162652128 @default.
• W1997806906 cites W2167444679 @default.
• W1997806906 cites W2169239588 @default.
• W1997806906 cites W2170330566 @default.
• W1997806906 cites W3104828118 @default.
• W1997806906 doi "https://doi.org/10.1016/j.vaccine.2011.02.043" @default.
• W1997806906 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3105354" @default.
• W1997806906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21377509" @default.
• W1997806906 hasPublicationYear "2011" @default.
• W1997806906 type Work @default.
• W1997806906 sameAs 1997806906 @default.
• W1997806906 citedByCount "39" @default.
• W1997806906 countsByYear W19978069062012 @default.
• W1997806906 countsByYear W19978069062013 @default.
• W1997806906 countsByYear W19978069062014 @default.
• W1997806906 countsByYear W19978069062015 @default.
• W1997806906 countsByYear W19978069062016 @default.
• W1997806906 countsByYear W19978069062017 @default.
• W1997806906 countsByYear W19978069062018 @default.
• W1997806906 countsByYear W19978069062019 @default.
• W1997806906 countsByYear W19978069062020 @default.
• W1997806906 countsByYear W19978069062023 @default.
• W1997806906 crossrefType "journal-article" @default.
• W1997806906 hasAuthorship W1997806906A5010601658 @default.
• W1997806906 hasAuthorship W1997806906A5028974096 @default.
• W1997806906 hasAuthorship W1997806906A5036633698 @default.
• W1997806906 hasAuthorship W1997806906A5036869113 @default.
• W1997806906 hasAuthorship W1997806906A5043080193 @default.
• W1997806906 hasAuthorship W1997806906A5058850764 @default.
• W1997806906 hasAuthorship W1997806906A5059355135 @default.
• W1997806906 hasAuthorship W1997806906A5064066871 @default.
• W1997806906 hasAuthorship W1997806906A5073651161 @default.
• W1997806906 hasAuthorship W1997806906A5074126857 @default.
• W1997806906 hasAuthorship W1997806906A5075202938 @default.
• W1997806906 hasBestOaLocation W19978069062 @default.
• W1997806906 hasConcept C104317684 @default.
• W1997806906 hasConcept C133239900 @default.
• W1997806906 hasConcept C134164806 @default.
• W1997806906 hasConcept C159047783 @default.
• W1997806906 hasConcept C159654299 @default.
• W1997806906 hasConcept C182072434 @default.
• W1997806906 hasConcept C203014093 @default.
• W1997806906 hasConcept C22070199 @default.
• W1997806906 hasConcept C2522874641 @default.
• W1997806906 hasConcept C2776090121 @default.
• W1997806906 hasConcept C2776872762 @default.
• W1997806906 hasConcept C2777546802 @default.
• W1997806906 hasConcept C2778692840 @default.
• W1997806906 hasConcept C2779053233 @default.
• W1997806906 hasConcept C2780689484 @default.
• W1997806906 hasConcept C2780868878 @default.
• W1997806906 hasConcept C2781416681 @default.
• W1997806906 hasConcept C32611913 @default.
• W1997806906 hasConcept C54602769 @default.
• W1997806906 hasConcept C55493867 @default.
• W1997806906 hasConcept C60987743 @default.
• W1997806906 hasConcept C71924100 @default.
• W1997806906 hasConcept C86803240 @default.

• next