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Matches in SemOpenAlex for { <https://semopenalex.org/work/W199780810> ?p ?o ?g. }

• W199780810 abstract "In an attempt to achieve post-inhalation self-regulated insulin release, we constructed a microparticle agglomerate of nano-sized liposomal particles, with the agglomeration facilitated by cross-linkages capable of cleavage by glucose. The particles exhibited a small aerodynamic diameter within the human respirable range, but a large geometric diameter that prevents macrophage uptake and clearance. Upon intratracheal instillation of the glucose-sensitive microparticle into the lungs of rats, hyperglycemic events triggered an acceleration of the release of insulin achieving normoglycemia shortly after sensing the elevated systemic glucose. This work is a demonstration of an inhalable particle with long residence times in the lungs capable of modulating insulin release based on systemic glucose levels." @default.
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• W199780810 date "2007-01-01" @default.
• W199780810 modified "2023-09-23" @default.
• W199780810 title "Glucose-sensing pulmonary delivery of human insulin to the systemic circulation of rats." @default.
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• W199780810 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2676664" @default.
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