FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997819076> ?p ?o ?g. }

• W1997819076 endingPage "286" @default.
• W1997819076 startingPage "278" @default.
• W1997819076 abstract "Tibia fracture in rats evokes nociceptive, vascular, and bone changes resembling complex regional pain syndrome (CRPS). Substance P (SP) signaling contributes to the hindpaw warmth, increased vascular permeability, and edema observed in this model, suggesting that neurogenic inflammatory responses could be enhanced after fracture. Four weeks after tibia fracture we measured SP and calcitonin gene-related peptide (CGRP) protein levels in the sciatic nerve and serum. Hindpaw skin extravasation responses and SP receptor (NK1), CGRP receptor (calcitonin receptor-like receptor, CRLR) and neutral endopeptidase (NEP) protein levels were also determined. Gene expression levels of these peptides, receptors, and peptidase were examined in the DRG and skin. Spontaneous and intravenous SP-evoked extravasation responses were increased ipsilateral, but not contralateral to the fracture. Fracture increased SP and CGRP gene expression in the ipsilateral L4,L5 DRG and neuropeptide protein levels in the sciatic nerve and in serum, but had no effect on electrically evoked SP and CGRP release. NK1 receptor expression was increased in the ipsilateral hindpaw skin keratinocytes and endothelial cells after injury, but CRLR and NEP expression were unchanged. Fracture also increased epidermal thickness, but had no effect on epidermal skin neurite counts. These results demonstrate that spontaneous and intravenous SP-evoked extravasation responses are enhanced in the ipsilateral hindlimb after fracture and that fracture chronically increases the expression of endothelial and keratinocyte NK1 receptors in the injured limb. We postulate that SP activation of these up-regulated NK1 receptors results in skin warmth, protein leakage, edema, and keratinocyte proliferation in the injured limb." @default.
• W1997819076 created "2016-06-24" @default.
• W1997819076 creator A5020062882 @default.
• W1997819076 creator A5027575817 @default.
• W1997819076 creator A5048023375 @default.
• W1997819076 creator A5049621128 @default.
• W1997819076 creator A5052787170 @default.
• W1997819076 creator A5056384169 @default.
• W1997819076 creator A5059918913 @default.
• W1997819076 creator A5073993417 @default.
• W1997819076 creator A5090603265 @default.
• W1997819076 date "2009-08-01" @default.
• W1997819076 modified "2023-10-17" @default.
• W1997819076 title "Post-junctional facilitation of Substance P signaling in a tibia fracture rat model of complex regional pain syndrome type I" @default.
• W1997819076 cites W1601444920 @default.
• W1997819076 cites W1976024859 @default.
• W1997819076 cites W1981912417 @default.
• W1997819076 cites W1985734972 @default.
• W1997819076 cites W1987637078 @default.
• W1997819076 cites W1997833318 @default.
• W1997819076 cites W1998677393 @default.
• W1997819076 cites W2012701523 @default.
• W1997819076 cites W2014767524 @default.
• W1997819076 cites W2020243063 @default.
• W1997819076 cites W2022779476 @default.
• W1997819076 cites W2022973904 @default.
• W1997819076 cites W2036815564 @default.
• W1997819076 cites W2039637232 @default.
• W1997819076 cites W2043232348 @default.
• W1997819076 cites W2050591899 @default.
• W1997819076 cites W2054394062 @default.
• W1997819076 cites W2061771411 @default.
• W1997819076 cites W2064851589 @default.
• W1997819076 cites W2072851012 @default.
• W1997819076 cites W2087454739 @default.
• W1997819076 cites W2096842237 @default.
• W1997819076 cites W2107866503 @default.
• W1997819076 cites W2142402689 @default.
• W1997819076 cites W2146308879 @default.
• W1997819076 cites W2151771466 @default.
• W1997819076 cites W2158396577 @default.
• W1997819076 cites W2161572010 @default.
• W1997819076 cites W2161978350 @default.
• W1997819076 cites W2171204926 @default.
• W1997819076 cites W2185164773 @default.
• W1997819076 cites W2963601092 @default.
• W1997819076 doi "https://doi.org/10.1016/j.pain.2009.04.020" @default.
• W1997819076 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2706925" @default.
• W1997819076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19464118" @default.
• W1997819076 hasPublicationYear "2009" @default.
• W1997819076 type Work @default.
• W1997819076 sameAs 1997819076 @default.
• W1997819076 citedByCount "80" @default.
• W1997819076 countsByYear W19978190762012 @default.
• W1997819076 countsByYear W19978190762013 @default.
• W1997819076 countsByYear W19978190762014 @default.
• W1997819076 countsByYear W19978190762015 @default.
• W1997819076 countsByYear W19978190762016 @default.
• W1997819076 countsByYear W19978190762017 @default.
• W1997819076 countsByYear W19978190762018 @default.
• W1997819076 countsByYear W19978190762019 @default.
• W1997819076 countsByYear W19978190762020 @default.
• W1997819076 countsByYear W19978190762021 @default.
• W1997819076 countsByYear W19978190762022 @default.
• W1997819076 countsByYear W19978190762023 @default.
• W1997819076 crossrefType "journal-article" @default.
• W1997819076 hasAuthorship W1997819076A5020062882 @default.
• W1997819076 hasAuthorship W1997819076A5027575817 @default.
• W1997819076 hasAuthorship W1997819076A5048023375 @default.
• W1997819076 hasAuthorship W1997819076A5049621128 @default.
• W1997819076 hasAuthorship W1997819076A5052787170 @default.
• W1997819076 hasAuthorship W1997819076A5056384169 @default.
• W1997819076 hasAuthorship W1997819076A5059918913 @default.
• W1997819076 hasAuthorship W1997819076A5073993417 @default.
• W1997819076 hasAuthorship W1997819076A5090603265 @default.
• W1997819076 hasBestOaLocation W19978190762 @default.
• W1997819076 hasConcept C105702510 @default.
• W1997819076 hasConcept C118303440 @default.
• W1997819076 hasConcept C126322002 @default.
• W1997819076 hasConcept C134018914 @default.
• W1997819076 hasConcept C142724271 @default.
• W1997819076 hasConcept C15490471 @default.
• W1997819076 hasConcept C163170386 @default.
• W1997819076 hasConcept C170493617 @default.
• W1997819076 hasConcept C2776089194 @default.
• W1997819076 hasConcept C2776533618 @default.
• W1997819076 hasConcept C2779245659 @default.
• W1997819076 hasConcept C2779540182 @default.
• W1997819076 hasConcept C2910052784 @default.
• W1997819076 hasConcept C71924100 @default.
• W1997819076 hasConcept C8337478 @default.
• W1997819076 hasConceptScore W1997819076C105702510 @default.
• W1997819076 hasConceptScore W1997819076C118303440 @default.
• W1997819076 hasConceptScore W1997819076C126322002 @default.
• W1997819076 hasConceptScore W1997819076C134018914 @default.
• W1997819076 hasConceptScore W1997819076C142724271 @default.
• W1997819076 hasConceptScore W1997819076C15490471 @default.
• W1997819076 hasConceptScore W1997819076C163170386 @default.

• next