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• W1997829202 abstract "U937 cell clones in which efficient (plus) vs poor (minus) replication of HIV-1 occurs have been described. We evaluated the role of host factors in their differential ability to support HIV-1 replication. Plus clones constitutively produced TNF-α and viral replication was inhibited by neutralization of endogenous TNF-α. However, HIV-1 replication was strongly upregulated in minus clones by exogenous TNF-α, which also further accelerated the kinetics of infection in plus clones. We observed an increased accumulation of proviral DNA within one round of HIV-1 replication following TNF-a treatment of plus cells. This effect was associated with increased surface density of CXCR4 in both plus and minus clones. Our results identify TNF-α as one correlate that contributes to the higher ability of U937-plus clones to sustain HIV-1 replication. Furthermore, we suggest that TNF-α may affect steps of the viral life cycle that occur earlier than transcription and also enhance HIV-1 replication by increasing the surface density of CXCR4." @default.
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• W1997829202 date "2001-01-01" @default.
• W1997829202 modified "2023-09-27" @default.
• W1997829202 title "TUMOR NECROSIS FACTOR-α DRIVES HIV-1 REPLICATION IN U937 CELL CLONES AND UPREGULATES CXCR4" @default.
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• W1997829202 doi "https://doi.org/10.1006/cyto.2000.0798" @default.
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