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- W1997872868 abstract "Objective: Elevated central systolic blood pressure (cSBP) is a validated risk factor for cardiovascular outcomes that may be more accurate than standard cuff blood pressure (BP) values due to inter-individual variations in pulse wave transmission and wave reflection. We report here the effects on central BP values obtained from pulse wave analysis (Sphygmocor, AtCor Medical, Sydney) comparing the combination of aliskiren and amlodipine (A+AML) with AML monotherapy in a subset (n=147) of a larger 8-week, prospective, multicenter, randomized, double-blind study (n=443) in African Americans with stage 2 hypertension. We have also reported that both office and 24-hour ambulatory BP values were lower with A+AML than AML. Design and Methods: Entry criteria included baseline mean sitting systolic BP (msSBP) >=160-<200 mmHg. Mean age of the randomized subjects was 53 ± 10 years. After a 1-4 week washout period, men and women were randomized to receive either A+AML 150/5 mg (n = 76) or AML 5 mg (n = 71) for 1 week; then the patients were force-titrated to receive A+AML 300/10 mg or AML 10 mg for 7 weeks. Results: The changes in central BP values from baseline to week 8 were significantly greater with A+AML than AML alone for cSBP (−29.8 vs −24.2; P < 0.05), central diastolic BP (-16.0 vs -9.9; P < 0.001), and central mean pressure (−21.9 vs −15.6; P < 0.001). There were no differences between treatment arms for the changes in central pulse pressure (PP), PP amplification ratio, or augmentation index. In the overall study, both treatments had similar tolerability. Conclusions: We conclude that the A+AML combination causes greater reductions in central blood pressures than AML monotherapy in African Americans with stage 2 hypertension." @default.
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- W1997872868 date "2010-06-01" @default.
- W1997872868 modified "2023-09-27" @default.
- W1997872868 title "ALISKIREN+AMLODIPINE COMBINATION REDUCES CENTRAL BLOOD PRESSURE MORE THAN AMLODIPINE ALONE IN AFRICAN AMERICANS WITH STAGE 2 HYPERTENSION: PP.5.171" @default.
- W1997872868 doi "https://doi.org/10.1097/01.hjh.0000378495.03146.bd" @default.
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