Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997882904> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W1997882904 endingPage "503" @default.
- W1997882904 startingPage "497" @default.
- W1997882904 abstract "Non-traditional C–H⋯Y hydrogen bonds, in which a carbon atom acts as the hydrogen donor and an electronegative atom Y (Y=N, O or S) acts as the acceptor, have been reported in proteins, but their importance in protein structures is not well established. Here, we present the results of three computational tests that examine the significance of C–H⋯Y bonds involving the Cα in proteins. First, we compared the number of Cα–H⋯Y bonds in native structures with two sets of compact, energy-minimized decoy structures. The decoy structures contain about as many Cα–H⋯Y bonds as the native structures, indicating that the constraints of chain connectivity and compactness can lead to incidental formation of Cα–H⋯Y bonds. Secondly, we examined whether short Cα–H⋯Y bonds have a tendency to be linear, as is expected for a cohesive hydrogen-bonding interaction. The native structures do show this trend, but so does one of the decoy sets, suggesting that this criterion is also not sufficient to indicate a stabilizing interaction. Finally, we examined the preference for Cα–H⋯Y bond donors to be near to strong hydrogen bond acceptors. In the native proteins, the alpha protons attract strong acceptors like oxygen atoms more than weak acceptors. In contrast, hydrogen bond donors in the decoy structures do not distinguish between strong and weak acceptors. Thus, any individual Cα–H⋯Y bond may be fortuitous and occur due to the polypeptide connectivity and compactness. Taken collectively, however, Cα–H⋯Y bonds provide a weakly cohesive force that stabilizes proteins." @default.
- W1997882904 created "2016-06-24" @default.
- W1997882904 creator A5017304834 @default.
- W1997882904 creator A5025950212 @default.
- W1997882904 date "2002-09-01" @default.
- W1997882904 modified "2023-10-17" @default.
- W1997882904 title "Evaluation of C–H⋯O Hydrogen Bonds in Native and Misfolded Proteins" @default.
- W1997882904 cites W1247114292 @default.
- W1997882904 cites W1965451259 @default.
- W1997882904 cites W1966239340 @default.
- W1997882904 cites W1971055676 @default.
- W1997882904 cites W1973382304 @default.
- W1997882904 cites W1980292953 @default.
- W1997882904 cites W1983271674 @default.
- W1997882904 cites W1989178532 @default.
- W1997882904 cites W1995017064 @default.
- W1997882904 cites W2011673894 @default.
- W1997882904 cites W2019863064 @default.
- W1997882904 cites W2030768463 @default.
- W1997882904 cites W2031920211 @default.
- W1997882904 cites W2040823078 @default.
- W1997882904 cites W2048084856 @default.
- W1997882904 cites W2051617312 @default.
- W1997882904 cites W2057184534 @default.
- W1997882904 cites W2064651645 @default.
- W1997882904 cites W2071545816 @default.
- W1997882904 cites W2080972330 @default.
- W1997882904 cites W2085764610 @default.
- W1997882904 cites W2090250026 @default.
- W1997882904 cites W2100314081 @default.
- W1997882904 cites W2128805758 @default.
- W1997882904 cites W2154106236 @default.
- W1997882904 cites W2154918056 @default.
- W1997882904 cites W2327855492 @default.
- W1997882904 doi "https://doi.org/10.1016/s0022-2836(02)00785-4" @default.
- W1997882904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12225744" @default.
- W1997882904 hasPublicationYear "2002" @default.
- W1997882904 type Work @default.
- W1997882904 sameAs 1997882904 @default.
- W1997882904 citedByCount "26" @default.
- W1997882904 countsByYear W19978829042014 @default.
- W1997882904 countsByYear W19978829042015 @default.
- W1997882904 countsByYear W19978829042016 @default.
- W1997882904 countsByYear W19978829042017 @default.
- W1997882904 countsByYear W19978829042019 @default.
- W1997882904 countsByYear W19978829042022 @default.
- W1997882904 crossrefType "journal-article" @default.
- W1997882904 hasAuthorship W1997882904A5017304834 @default.
- W1997882904 hasAuthorship W1997882904A5025950212 @default.
- W1997882904 hasConcept C112887158 @default.
- W1997882904 hasConcept C121332964 @default.
- W1997882904 hasConcept C170493617 @default.
- W1997882904 hasConcept C178790620 @default.
- W1997882904 hasConcept C185592680 @default.
- W1997882904 hasConcept C26873012 @default.
- W1997882904 hasConcept C2779179475 @default.
- W1997882904 hasConcept C2779892579 @default.
- W1997882904 hasConcept C32909587 @default.
- W1997882904 hasConcept C55493867 @default.
- W1997882904 hasConcept C71240020 @default.
- W1997882904 hasConcept C8010536 @default.
- W1997882904 hasConceptScore W1997882904C112887158 @default.
- W1997882904 hasConceptScore W1997882904C121332964 @default.
- W1997882904 hasConceptScore W1997882904C170493617 @default.
- W1997882904 hasConceptScore W1997882904C178790620 @default.
- W1997882904 hasConceptScore W1997882904C185592680 @default.
- W1997882904 hasConceptScore W1997882904C26873012 @default.
- W1997882904 hasConceptScore W1997882904C2779179475 @default.
- W1997882904 hasConceptScore W1997882904C2779892579 @default.
- W1997882904 hasConceptScore W1997882904C32909587 @default.
- W1997882904 hasConceptScore W1997882904C55493867 @default.
- W1997882904 hasConceptScore W1997882904C71240020 @default.
- W1997882904 hasConceptScore W1997882904C8010536 @default.
- W1997882904 hasIssue "3" @default.
- W1997882904 hasLocation W19978829041 @default.
- W1997882904 hasLocation W19978829042 @default.
- W1997882904 hasOpenAccess W1997882904 @default.
- W1997882904 hasPrimaryLocation W19978829041 @default.
- W1997882904 hasRelatedWork W1969695492 @default.
- W1997882904 hasRelatedWork W1979017969 @default.
- W1997882904 hasRelatedWork W1996887642 @default.
- W1997882904 hasRelatedWork W2049473277 @default.
- W1997882904 hasRelatedWork W2079346183 @default.
- W1997882904 hasRelatedWork W2500179633 @default.
- W1997882904 hasRelatedWork W2788975530 @default.
- W1997882904 hasRelatedWork W2973254198 @default.
- W1997882904 hasRelatedWork W3094816455 @default.
- W1997882904 hasRelatedWork W646380683 @default.
- W1997882904 hasVolume "322" @default.
- W1997882904 isParatext "false" @default.
- W1997882904 isRetracted "false" @default.
- W1997882904 magId "1997882904" @default.
- W1997882904 workType "article" @default.