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• W1997884805 abstract "CB 1954, a monofunctional alkylating agent, has exceptional activity against the Walker carcinoma yet is inactive against a large number of other animal tumours. A line of the Walker tumour with acquired resistance to CB 1954 was cross-resistant to Melphalan, implying a common mechanism of action, although other tumours highly sensitive to Melphalan were not affected by CB 1954. CB 1954 was also similar to Melphalan in its effects on DNA and RNA synthesis. No correlation was observed between binding of CB 1954 to the DNA of tumour cells and their sensitivity to it. Differences in response of the Walker tumour when incubated with Melphalan and CB 1954 suggest that the latter agent may have some features of an anti-metabolite. In preliminary experiments, its selective anti-tumour effect against the Walker carcinoma has been completely reversed by an intermediate in purine biosynthesis. Etude du Mecanisme de L'action Selectif de la Tumeur de Walker du .5-Aziridinyl-2,4-Dinltrobenza M I de (CB 1954), un Inhibiteur Selectif de la Tumeur de Walker Le CB 1954, un agent alcoïlant monofonctionnel, fait preuve d'une activité exceptionnelle envers l'epithélioma de Walker alors qu'il n'a aucun effet sur un grand nombre d'autres tumeurs animales. Une souche de la tumeur de Walker ayant acquis une résistance au CB 1954 a fait preuve d'une résistance croisée envers le Melphalan, ce qui implique un mécanisme d'action commun, bien que d'autres tumeurs fortement sensibles au Melphalan ne soient pas affectées par le CB 1954. Cet agent est encore semblable au Melphalan quant à ses effets sur la synthèse de l'ARN ou de l'ADN. Aucune corrélation n'a été observée entre la liaison du CB 1954 avec l'ADN des cellules tumorales et leur sensibilité à son égard. Les différences caractérisant la réponse de la tumeur de Walker incubée avec du Melphalan et du CB 1954 donnent à penser que ce dernier agent a peut-ětre certaines caractéristiques d'un antimétabolite. Lors des expériences préliminaires, son effet antitumoral sélectif envers l'épithélioma de Walker a été complètement inversé par un intermédiaire au cours de la biosynthèse de la purine." @default.
• W1997884805 created "2016-06-24" @default.
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• W1997884805 date "1971-01-15" @default.
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• W1997884805 title "Studies on the mechanism of action of 5-aziridinyl-2,4-dinitrobenzamide (CB 1954), a selective inhibitor of the walker tumour" @default.
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• W1997884805 doi "https://doi.org/10.1002/ijc.2910070110" @default.
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