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- W1997887659 abstract "Human osteosarcoma and mammary carcinoma cells were cultured separately in a medium supplemented with fetal calf serum, until they were confluent. The medium was then replaced by serum-free medium supplemented with heparin. Both cell cultures secreted collagenase, and this activity was inhibited by a cartilage-derived protein of low molecular weight. Since cartilage is rarely invaded by neoplasms, the presence of this inhibitor may play an important role in the regulation of tumor invasion." @default.
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- W1997887659 date "1977-05-06" @default.
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- W1997887659 title "Tumor Cell Collagenase and Its Inhibition by a Cartilage-Derived Protease Inhibitor" @default.
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- W1997887659 doi "https://doi.org/10.1126/science.193181" @default.
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