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- W1997891492 abstract "The effect of calcitonin (CT) on calcium content and enzyme activity in the hepatic mitochondria of intact rats was investigated. A single subcutaneous administration of CT (80 MRC mU/100g BW) produced a significant increase in the content of calcium, the activity of pyruvate carboxylase, succinate dehydrogenase and ATPase 15min after the hormone treatment. The significant increases in calcium content and pyruvate carboxylase activity were also observed 30min after CT administration, while succinate dehydrogenase and ATPase activity began to decrease. A physiological dose of CT (20 MRC mU/100g BW) caused a marked increase in calcium content and pyruvate carboxylase activity but not succinate dehydrogenase or ATPaseactivity. The removal of calcium by 10mM EGTA washing of the mitochondria produced a remarkable reduction in pyruvate carboxylase activity increased by CT administration. The addition of calcium ion of 2.5×10-2-2.5×101nmoles Ca2+ per mg mitochondrial protein produced a marked increase in pyruvate carboxylase activity. The present results suggest that calcium taken up by the hepatic mitochondria after CT administration activates pyruvate carboxylase." @default.
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- W1997891492 date "1981-01-01" @default.
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- W1997891492 title "Calcitonin increases pyruvate carboxylase activity in hepatic mitochondria of rats." @default.
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- W1997891492 doi "https://doi.org/10.1507/endocrj1954.28.709" @default.
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