FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997899268> ?p ?o ?g. }

• W1997899268 endingPage "334" @default.
• W1997899268 startingPage "327" @default.
• W1997899268 abstract "Rationale: The clinical problem of loss of β-adrenergic receptor (β-AR) response, both in the pathogenesis of heart failure and during therapeutic application of β-agonists, is attributable, at least in part, to desensitization, internalization, and downregulation of the receptors. In the regulation of β-AR signaling, G protein–coupled receptor kinase 2 (GRK2) primarily phosphorylates agonist-occupied β-ARs, and this modification promotes desensitization, internalization, and downregulation of β-ARs. It has been demonstrated that GRK2 is inhibited by its S-nitrosylation. However, compounds that induce S-nitrosylation, such as S-nitrosoglutathione, simultaneously generate NO, which has been demonstrated to operate for cardiovascular protection. Objective: We examine whether S-nitrosylation without NO generation inhibits desensitization of β 2 -AR by GRK2. We thus aim to synthesize compounds that specifically induce S-nitrosylation. Methods and Results: We have developed water-soluble N-nitrosamines that have S-nitrosylating activity but lack NO-generating activity. These compounds, at least partly, rescue β-AR from desensitization in HEK 293 cells expressing FLAG-tagged human β 2 -AR and in rat cardiac myocytes. They inhibit isoproterenol-dependent phosphorylation and internalization of β 2 -AR. Indeed, they nitrosylate GRK2 in vitro and in cells, and their S-nitrosylation of GRK2 likely underlies their inhibition of β 2 -AR desensitization. Conclusions: Compounds that induce S-nitrosylation without NO release inhibit GRK2 and attenuate β 2 -AR desensitization. Developing water-soluble drugs that specifically induce S-nitrosylation may be a promising therapeutic strategy for heart failure." @default.
• W1997899268 created "2016-06-24" @default.
• W1997899268 creator A5000396315 @default.
• W1997899268 creator A5004716150 @default.
• W1997899268 creator A5011925781 @default.
• W1997899268 creator A5019408447 @default.
• W1997899268 creator A5019731803 @default.
• W1997899268 creator A5022044182 @default.
• W1997899268 creator A5027596651 @default.
• W1997899268 creator A5036113498 @default.
• W1997899268 creator A5063887149 @default.
• W1997899268 creator A5071535350 @default.
• W1997899268 creator A5081309743 @default.
• W1997899268 creator A5088064026 @default.
• W1997899268 date "2013-01-18" @default.
• W1997899268 modified "2023-09-30" @default.
• W1997899268 title "Attenuated Desensitization of β-Adrenergic Receptor by Water-Soluble N-Nitrosamines That Induce S-Nitrosylation Without NO Release" @default.
• W1997899268 cites W1692500298 @default.
• W1997899268 cites W1699017532 @default.
• W1997899268 cites W1977190827 @default.
• W1997899268 cites W1988097700 @default.
• W1997899268 cites W1990651138 @default.
• W1997899268 cites W1992254322 @default.
• W1997899268 cites W1999532619 @default.
• W1997899268 cites W2003476666 @default.
• W1997899268 cites W2006142006 @default.
• W1997899268 cites W2013989605 @default.
• W1997899268 cites W2014972823 @default.
• W1997899268 cites W2039979152 @default.
• W1997899268 cites W2041756859 @default.
• W1997899268 cites W2055375040 @default.
• W1997899268 cites W2064664612 @default.
• W1997899268 cites W2078748771 @default.
• W1997899268 cites W2080031356 @default.
• W1997899268 cites W2081952060 @default.
• W1997899268 cites W2084680099 @default.
• W1997899268 cites W2105012896 @default.
• W1997899268 cites W2111309849 @default.
• W1997899268 cites W2118532526 @default.
• W1997899268 cites W2119398013 @default.
• W1997899268 cites W2126129355 @default.
• W1997899268 cites W2127162896 @default.
• W1997899268 cites W2129415401 @default.
• W1997899268 cites W2140820106 @default.
• W1997899268 cites W2143004446 @default.
• W1997899268 cites W2147196684 @default.
• W1997899268 cites W2167742611 @default.
• W1997899268 cites W2167857702 @default.
• W1997899268 cites W2324258168 @default.
• W1997899268 doi "https://doi.org/10.1161/circresaha.112.277665" @default.
• W1997899268 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23212582" @default.
• W1997899268 hasPublicationYear "2013" @default.
• W1997899268 type Work @default.
• W1997899268 sameAs 1997899268 @default.
• W1997899268 citedByCount "21" @default.
• W1997899268 countsByYear W19978992682013 @default.
• W1997899268 countsByYear W19978992682015 @default.
• W1997899268 countsByYear W19978992682016 @default.
• W1997899268 countsByYear W19978992682017 @default.
• W1997899268 countsByYear W19978992682018 @default.
• W1997899268 countsByYear W19978992682019 @default.
• W1997899268 countsByYear W19978992682020 @default.
• W1997899268 countsByYear W19978992682021 @default.
• W1997899268 countsByYear W19978992682022 @default.
• W1997899268 countsByYear W19978992682023 @default.
• W1997899268 crossrefType "journal-article" @default.
• W1997899268 hasAuthorship W1997899268A5000396315 @default.
• W1997899268 hasAuthorship W1997899268A5004716150 @default.
• W1997899268 hasAuthorship W1997899268A5011925781 @default.
• W1997899268 hasAuthorship W1997899268A5019408447 @default.
• W1997899268 hasAuthorship W1997899268A5019731803 @default.
• W1997899268 hasAuthorship W1997899268A5022044182 @default.
• W1997899268 hasAuthorship W1997899268A5027596651 @default.
• W1997899268 hasAuthorship W1997899268A5036113498 @default.
• W1997899268 hasAuthorship W1997899268A5063887149 @default.
• W1997899268 hasAuthorship W1997899268A5071535350 @default.
• W1997899268 hasAuthorship W1997899268A5081309743 @default.
• W1997899268 hasAuthorship W1997899268A5088064026 @default.
• W1997899268 hasBestOaLocation W19978992681 @default.
• W1997899268 hasConcept C104317684 @default.
• W1997899268 hasConcept C11960822 @default.
• W1997899268 hasConcept C127561419 @default.
• W1997899268 hasConcept C135285700 @default.
• W1997899268 hasConcept C139770010 @default.
• W1997899268 hasConcept C170493617 @default.
• W1997899268 hasConcept C178790620 @default.
• W1997899268 hasConcept C181199279 @default.
• W1997899268 hasConcept C185592680 @default.
• W1997899268 hasConcept C2777553025 @default.
• W1997899268 hasConcept C2778938600 @default.
• W1997899268 hasConcept C2779201268 @default.
• W1997899268 hasConcept C2779779143 @default.
• W1997899268 hasConcept C33235085 @default.
• W1997899268 hasConcept C45068187 @default.
• W1997899268 hasConcept C519581460 @default.
• W1997899268 hasConcept C55493867 @default.
• W1997899268 hasConcept C78976303 @default.
• W1997899268 hasConcept C86803240 @default.

• next