Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997904519> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W1997904519 endingPage "1126" @default.
- W1997904519 startingPage "1121" @default.
- W1997904519 abstract "The intention of this study was to determine whether type IA antiarrhythmic drugs cause a disparity between refractoriness and repolarization, and if so, its magnitude. We simultaneously measured monophasic action potential duration (MAPD) and effective refractory period (ERP) at a right ventricular site in 11 patients without overt right ventricular disease. The pacing protocol, which included sinus rhythm and a 600 and 400 msec cycle length of ventricular drive, was performed at baseline and after the intravenous administration of 15 mg/kg of procainamide in nine patients, and of 10 mg/kg of quinidine in two patients. Despite trivial changes in sinus rates, drug therapy caused a 10% to 17% increase in MAPD and ERP that shortened with decreasing drive cycle lengths. At baseline there was a small gap (10 to 13 msec) between MAPD and ERP in sinus rhythm and with a 600 or 400 msec drive. However, the type IA drug caused a significant widening of this gap that was most profound in sinus rhythm (45 msec) and that shortened but was not abolished with a 600 and 400 msec drive (28 and 29 msec, respectively). The disparity was caused in one third of cases by postrepolarization refractoriness. Type I drugs increase the difference between repolarization and refractoriness, and this effect is partially reversed with increases in heart rate. The clinical implications of these findings are discussed." @default.
- W1997904519 created "2016-06-24" @default.
- W1997904519 creator A5001241147 @default.
- W1997904519 creator A5017379008 @default.
- W1997904519 creator A5037931008 @default.
- W1997904519 creator A5049355462 @default.
- W1997904519 creator A5059826669 @default.
- W1997904519 date "1993-11-01" @default.
- W1997904519 modified "2023-09-24" @default.
- W1997904519 title "Evidence for a reexcitability gap in man after treatment with type I antiarrhythmic drugs" @default.
- W1997904519 cites W1913866372 @default.
- W1997904519 cites W1966865981 @default.
- W1997904519 cites W1973729956 @default.
- W1997904519 cites W1979703010 @default.
- W1997904519 cites W1995264625 @default.
- W1997904519 cites W1995907435 @default.
- W1997904519 cites W1999756294 @default.
- W1997904519 cites W2001098717 @default.
- W1997904519 cites W2006584081 @default.
- W1997904519 cites W2012972549 @default.
- W1997904519 cites W2020859911 @default.
- W1997904519 cites W2039289213 @default.
- W1997904519 cites W2040954869 @default.
- W1997904519 cites W2043125220 @default.
- W1997904519 cites W2044097193 @default.
- W1997904519 cites W2047838671 @default.
- W1997904519 cites W2067721452 @default.
- W1997904519 cites W2068795851 @default.
- W1997904519 cites W2069538677 @default.
- W1997904519 cites W2073306342 @default.
- W1997904519 cites W2093465664 @default.
- W1997904519 cites W2113759120 @default.
- W1997904519 cites W2125550345 @default.
- W1997904519 cites W2155960712 @default.
- W1997904519 cites W2157758976 @default.
- W1997904519 cites W2161390745 @default.
- W1997904519 cites W2161601876 @default.
- W1997904519 cites W2416407745 @default.
- W1997904519 doi "https://doi.org/10.1016/0002-8703(93)90663-t" @default.
- W1997904519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8237754" @default.
- W1997904519 hasPublicationYear "1993" @default.
- W1997904519 type Work @default.
- W1997904519 sameAs 1997904519 @default.
- W1997904519 citedByCount "6" @default.
- W1997904519 countsByYear W19979045192012 @default.
- W1997904519 crossrefType "journal-article" @default.
- W1997904519 hasAuthorship W1997904519A5001241147 @default.
- W1997904519 hasAuthorship W1997904519A5017379008 @default.
- W1997904519 hasAuthorship W1997904519A5037931008 @default.
- W1997904519 hasAuthorship W1997904519A5049355462 @default.
- W1997904519 hasAuthorship W1997904519A5059826669 @default.
- W1997904519 hasConcept C126322002 @default.
- W1997904519 hasConcept C135343436 @default.
- W1997904519 hasConcept C146403970 @default.
- W1997904519 hasConcept C164705383 @default.
- W1997904519 hasConcept C185263204 @default.
- W1997904519 hasConcept C189327125 @default.
- W1997904519 hasConcept C2775914520 @default.
- W1997904519 hasConcept C2777028498 @default.
- W1997904519 hasConcept C2779161974 @default.
- W1997904519 hasConcept C42219234 @default.
- W1997904519 hasConcept C70616116 @default.
- W1997904519 hasConcept C71924100 @default.
- W1997904519 hasConceptScore W1997904519C126322002 @default.
- W1997904519 hasConceptScore W1997904519C135343436 @default.
- W1997904519 hasConceptScore W1997904519C146403970 @default.
- W1997904519 hasConceptScore W1997904519C164705383 @default.
- W1997904519 hasConceptScore W1997904519C185263204 @default.
- W1997904519 hasConceptScore W1997904519C189327125 @default.
- W1997904519 hasConceptScore W1997904519C2775914520 @default.
- W1997904519 hasConceptScore W1997904519C2777028498 @default.
- W1997904519 hasConceptScore W1997904519C2779161974 @default.
- W1997904519 hasConceptScore W1997904519C42219234 @default.
- W1997904519 hasConceptScore W1997904519C70616116 @default.
- W1997904519 hasConceptScore W1997904519C71924100 @default.
- W1997904519 hasIssue "5" @default.
- W1997904519 hasLocation W19979045191 @default.
- W1997904519 hasLocation W19979045192 @default.
- W1997904519 hasOpenAccess W1997904519 @default.
- W1997904519 hasPrimaryLocation W19979045191 @default.
- W1997904519 hasRelatedWork W1997904519 @default.
- W1997904519 hasRelatedWork W2006584081 @default.
- W1997904519 hasRelatedWork W2053905738 @default.
- W1997904519 hasRelatedWork W2062486139 @default.
- W1997904519 hasRelatedWork W2069538677 @default.
- W1997904519 hasRelatedWork W2109769175 @default.
- W1997904519 hasRelatedWork W2329283338 @default.
- W1997904519 hasRelatedWork W2369647917 @default.
- W1997904519 hasRelatedWork W2389895109 @default.
- W1997904519 hasRelatedWork W4253812676 @default.
- W1997904519 hasVolume "126" @default.
- W1997904519 isParatext "false" @default.
- W1997904519 isRetracted "false" @default.
- W1997904519 magId "1997904519" @default.
- W1997904519 workType "article" @default.