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- W1997905300 abstract "Nuclear factor-κB (NF-κB), a transcription factor mainly involved in stress-induced, immune and inflammatory responses, plays a critical role in the pathogenesis of several human diseases. It is activated in heart failureand endotoxemia, and its inhibition is associated with therapeutic effects in these conditions. NF-κB is also activated by angiotensin II, which can be inhibited using an angiotensin II receptor antagonist. Pimobendan, a phosphodiesterase type 3 (PDE3) inhibitor, suppresses the activation of NF-κB and improves the long-term prognosis in heart failure." @default.
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- W1997905300 date "2004-01-01" @default.
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- W1997905300 title "The role of NF-kappaB in the pathogenesis of heart failure and endotoxemia" @default.
- W1997905300 doi "https://doi.org/10.1358/dof.2004.029.07.854170" @default.
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