FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997917833> ?p ?o ?g. }

• W1997917833 endingPage "C655" @default.
• W1997917833 startingPage "C636" @default.
• W1997917833 abstract "Oxidative stress and endoplasmic reticulum (ER) stress are emerging as crucial events in the etiopathology of many neurodegenerative diseases. While the neuroprotective contributions of the dietary compound curcumin has been recognized, the molecular mechanisms underlying curcumin's neuroprotection under oxidative and ER stresses remains elusive. Herein, we show that curcumin protects HT22 from oxidative and ER stresses evoked by the hypoxia (1% O 2 or CoCl 2 treatment) by enhancing peroxiredoxin 6 (Prdx6) expression. Cells exposed to CoCl 2 displayed reduced expression of Prdx6 with higher reactive oxygen species (ROS) expression and activation of NF-κB with IκB phosphorylation. When NF-κB activity was blocked by using SN50, an inhibitor of NF-κB, or cells treated with curcumin, the repression of Prdx6 expression was restored, suggesting the involvement of NF-κB in modulating Prdx6 expression. These cells were enriched with an accumulation of ER stress proteins, C/EBP homologous protein (CHOP), GRP/78, and calreticulin, and had activated states of caspases 12, 9, and 3. Reinforced expression of Prdx6 in HT22 cells by curcumin reestablished survival signaling by reducing propagation of ROS and blunting ER stress signaling. Intriguingly, knockdown of Prdx6 by antisense revealed that loss of Prdx6 contributed to cell death by sustaining enhanced levels of ER stress-responsive proapoptotic proteins, which was due to elevated ROS production, suggesting that Prdx6 deficiency is a cause of initiation of ROS-mediated ER stress-induced apoptosis. We propose that using curcumin to reinforce the naturally occurring Prdx6 expression and attenuate ROS-based ER stress and NF-κB-mediated aberrant signaling improves cell survival and may provide an avenue to treat and/or postpone diseases associated with ROS or ER stress." @default.
• W1997917833 created "2016-06-24" @default.
• W1997917833 creator A5008356387 @default.
• W1997917833 creator A5010780653 @default.
• W1997917833 creator A5023917983 @default.
• W1997917833 creator A5064070682 @default.
• W1997917833 creator A5072279870 @default.
• W1997917833 creator A5075654225 @default.
• W1997917833 date "2013-04-01" @default.
• W1997917833 modified "2023-09-22" @default.
• W1997917833 title "Curcumin abates hypoxia-induced oxidative stress based-ER stress-mediated cell death in mouse hippocampal cells (HT22) by controlling Prdx6 and NF-κB regulation" @default.
• W1997917833 cites W1507360643 @default.
• W1997917833 cites W1568529372 @default.
• W1997917833 cites W1575226591 @default.
• W1997917833 cites W1577654298 @default.
• W1997917833 cites W1588470721 @default.
• W1997917833 cites W1966728645 @default.
• W1997917833 cites W1967058999 @default.
• W1997917833 cites W1972083248 @default.
• W1997917833 cites W1976919988 @default.
• W1997917833 cites W1982313380 @default.
• W1997917833 cites W1983904065 @default.
• W1997917833 cites W1983963897 @default.
• W1997917833 cites W1984678769 @default.
• W1997917833 cites W1984926678 @default.
• W1997917833 cites W1987330869 @default.
• W1997917833 cites W1988217531 @default.
• W1997917833 cites W1990815712 @default.
• W1997917833 cites W1991015116 @default.
• W1997917833 cites W1991825280 @default.
• W1997917833 cites W1992189713 @default.
• W1997917833 cites W1995002748 @default.
• W1997917833 cites W1996885323 @default.
• W1997917833 cites W2002022490 @default.
• W1997917833 cites W2005154363 @default.
• W1997917833 cites W2005922606 @default.
• W1997917833 cites W2009797189 @default.
• W1997917833 cites W2012875531 @default.
• W1997917833 cites W2014843089 @default.
• W1997917833 cites W2015454673 @default.
• W1997917833 cites W2016293448 @default.
• W1997917833 cites W2017138941 @default.
• W1997917833 cites W2017370353 @default.
• W1997917833 cites W2018935876 @default.
• W1997917833 cites W2021333182 @default.
• W1997917833 cites W2021777993 @default.
• W1997917833 cites W2024445551 @default.
• W1997917833 cites W2026236263 @default.
• W1997917833 cites W2027727753 @default.
• W1997917833 cites W2028372858 @default.
• W1997917833 cites W2029604124 @default.
• W1997917833 cites W2031279361 @default.
• W1997917833 cites W2032348969 @default.
• W1997917833 cites W2034459537 @default.
• W1997917833 cites W2040737652 @default.
• W1997917833 cites W2041079773 @default.
• W1997917833 cites W2041737513 @default.
• W1997917833 cites W2043097986 @default.
• W1997917833 cites W2045336410 @default.
• W1997917833 cites W2047797407 @default.
• W1997917833 cites W2050935157 @default.
• W1997917833 cites W2051343147 @default.
• W1997917833 cites W2051816907 @default.
• W1997917833 cites W2056611788 @default.
• W1997917833 cites W2059804383 @default.
• W1997917833 cites W2060662813 @default.
• W1997917833 cites W2061981941 @default.
• W1997917833 cites W2062118458 @default.
• W1997917833 cites W2062250649 @default.
• W1997917833 cites W2065747472 @default.
• W1997917833 cites W2067775412 @default.
• W1997917833 cites W2071626214 @default.
• W1997917833 cites W2081412929 @default.
• W1997917833 cites W2081731224 @default.
• W1997917833 cites W2083278580 @default.
• W1997917833 cites W2084101023 @default.
• W1997917833 cites W2084817274 @default.
• W1997917833 cites W2085987728 @default.
• W1997917833 cites W2086421062 @default.
• W1997917833 cites W2088971374 @default.
• W1997917833 cites W2089603209 @default.
• W1997917833 cites W2089952442 @default.
• W1997917833 cites W2093330856 @default.
• W1997917833 cites W2094873226 @default.
• W1997917833 cites W2117400125 @default.
• W1997917833 cites W2118210890 @default.
• W1997917833 cites W2119610385 @default.
• W1997917833 cites W2121264285 @default.
• W1997917833 cites W2122395558 @default.
• W1997917833 cites W2126320385 @default.
• W1997917833 cites W2132411546 @default.
• W1997917833 cites W2136740555 @default.
• W1997917833 cites W2143118702 @default.
• W1997917833 cites W2150202137 @default.
• W1997917833 cites W2151300092 @default.
• W1997917833 cites W2156156861 @default.
• W1997917833 cites W2158354886 @default.
• W1997917833 cites W2158496331 @default.

• next