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- W199792009 abstract "Reproductive health is a dynamic part of our lives with a broad spectrum of events.Study of twins can assist to investigate the relationship between environmental andhereditary causes of reproductive diseases, which would otherwise be difficult if notimpossible to study. High concordance between twin pairs suggests a strong influencefor genetic factors, whereas low concordance indicates a weak influence. Preventivemeasures can be taken into consideration for those who are at risk of environmentalinfluences if and only when the role of genetic is minor even though gene therapy mayminimize the occurrence of genetic disease.This cross-sectional descriptive study of reproductive health of twins investigated theheritability of qualitative and quantitative measured variables related to reproductiveevents or behavior of adult twins. Subjects included 156 identical and 110 non-identicaltwins, 15 years and above who were living in urban areas of Iran and Malaysia. Basicand modern genetic analysis was adopted. Maximum likelihood analysis and model fitting analysis suggested that birth weight, weight, height, age of menarche,premenstrual symptoms, acne, hirsutism, baldness and infertility are mostly determinedby genetic factors while characteristics of menstruation were more likely under theinfluence of environmental factors. Classical genetic analysis using Falconer’s formulasuggested higher similarity between monozygotic twins than dyzyotics in relation toreproductive behaviors such as age of first pregnancy and number of pregnancies.Probandwise concordance rate analysis showed higher similarity between identical twinsin adopting correct reproductive behavior such as undergoing pap smear and usingfamily planning techniques. Model fitting analysis for the ACE model supported thesefindings.Same-sex twins had a higher risk of congenital abnormality, gynecological problem, andirregular menstruation than opposite sex twins. Other reproductive events were notfound to be significantly different between the two groups indicating that hormonaltransition from male to female may not be a valid explanation for reproductive ill health.Birth weight was not found to affect reproductive morbidity during adult life asfrequency of reproductive event was found to be higher among low birth weight twinscompared with normal weight twins. This finding is not consistent with fetal originhypothesis or thrifty gene hypothesis.Reproductive ill-health influenced by environmental factors may be minimized usingcareful primary care evaluation, early detection and prevention while genetic predisposition can be monitored for those variables under genetic influence. Earlyreproductive health consultation for adolescents is recommended to avoid complicationsof reproductive ill-health." @default.
- W199792009 created "2016-06-24" @default.
- W199792009 creator A5061291374 @default.
- W199792009 date "2007-01-01" @default.
- W199792009 modified "2023-09-27" @default.
- W199792009 title "Influence of Environment and Genetics on Reproductive Health of Twins" @default.
- W199792009 hasPublicationYear "2007" @default.
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