Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997923283> ?p ?o ?g. }
- W1997923283 endingPage "7" @default.
- W1997923283 startingPage "1" @default.
- W1997923283 abstract "The present study was designed to investigate which subtype of spinal 5-HT receptors were involved in acetaminophen-induced antinociception using the paw-pressure test. Propacetamol (prodrug of acetaminophen, 400 mg/kg, injected intravenously, corresponding to 200 mg/kg of acetaminophen) produced a significant antinociceptive effect in this test. This effect was at least partially inhibited by intrathecal (i.t.) pretreatment with the 5-HT(1B) (penbutolol), 5-HT(2A) (ketanserin), 5-HT(2C) (mesulergine) receptor antagonists, but not by the 5-HT(1A) (N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide trihydrochloride, WAY 100635) and 5-HT(3) (granisetron) receptor antagonists. This profile was very close to that obtained recently with 5-HT, which suggests an implication of 5-HT in the spinal antinociceptive effect of acetaminophen. These results, the lack of binding of acetaminophen to 5-HT receptors and the increase of central 5-HT levels induced by this drug suggest that acetaminophen-induced antinociception could be indirectly mediated by 5-HT." @default.
- W1997923283 created "2016-06-24" @default.
- W1997923283 creator A5037542474 @default.
- W1997923283 creator A5042292568 @default.
- W1997923283 creator A5075478051 @default.
- W1997923283 creator A5080830822 @default.
- W1997923283 creator A5090623250 @default.
- W1997923283 date "2001-11-01" @default.
- W1997923283 modified "2023-09-26" @default.
- W1997923283 title "5-HT receptor subtypes involved in the spinal antinociceptive effect of acetaminophen in rats" @default.
- W1997923283 cites W1497042115 @default.
- W1997923283 cites W1974144737 @default.
- W1997923283 cites W1978091898 @default.
- W1997923283 cites W1980088002 @default.
- W1997923283 cites W1982324672 @default.
- W1997923283 cites W1982914159 @default.
- W1997923283 cites W1998165780 @default.
- W1997923283 cites W2003880412 @default.
- W1997923283 cites W2004522624 @default.
- W1997923283 cites W2011188320 @default.
- W1997923283 cites W2028855732 @default.
- W1997923283 cites W2032641845 @default.
- W1997923283 cites W2038410983 @default.
- W1997923283 cites W2043323520 @default.
- W1997923283 cites W2053236356 @default.
- W1997923283 cites W2054350114 @default.
- W1997923283 cites W2054389443 @default.
- W1997923283 cites W2056761692 @default.
- W1997923283 cites W2056951535 @default.
- W1997923283 cites W2057990158 @default.
- W1997923283 cites W2061327109 @default.
- W1997923283 cites W2062692788 @default.
- W1997923283 cites W2067558789 @default.
- W1997923283 cites W2086898945 @default.
- W1997923283 cites W2089736075 @default.
- W1997923283 cites W2092667479 @default.
- W1997923283 cites W4235913487 @default.
- W1997923283 doi "https://doi.org/10.1016/s0014-2999(01)01464-9" @default.
- W1997923283 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11734181" @default.
- W1997923283 hasPublicationYear "2001" @default.
- W1997923283 type Work @default.
- W1997923283 sameAs 1997923283 @default.
- W1997923283 citedByCount "64" @default.
- W1997923283 countsByYear W19979232832012 @default.
- W1997923283 countsByYear W19979232832013 @default.
- W1997923283 countsByYear W19979232832014 @default.
- W1997923283 countsByYear W19979232832015 @default.
- W1997923283 countsByYear W19979232832016 @default.
- W1997923283 countsByYear W19979232832017 @default.
- W1997923283 countsByYear W19979232832018 @default.
- W1997923283 countsByYear W19979232832019 @default.
- W1997923283 countsByYear W19979232832020 @default.
- W1997923283 countsByYear W19979232832021 @default.
- W1997923283 countsByYear W19979232832022 @default.
- W1997923283 crossrefType "journal-article" @default.
- W1997923283 hasAuthorship W1997923283A5037542474 @default.
- W1997923283 hasAuthorship W1997923283A5042292568 @default.
- W1997923283 hasAuthorship W1997923283A5075478051 @default.
- W1997923283 hasAuthorship W1997923283A5080830822 @default.
- W1997923283 hasAuthorship W1997923283A5090623250 @default.
- W1997923283 hasConcept C15490471 @default.
- W1997923283 hasConcept C170493617 @default.
- W1997923283 hasConcept C185592680 @default.
- W1997923283 hasConcept C2775864247 @default.
- W1997923283 hasConcept C2777785214 @default.
- W1997923283 hasConcept C2778722691 @default.
- W1997923283 hasConcept C2780820201 @default.
- W1997923283 hasConcept C53910766 @default.
- W1997923283 hasConcept C55493867 @default.
- W1997923283 hasConcept C71924100 @default.
- W1997923283 hasConcept C98274493 @default.
- W1997923283 hasConceptScore W1997923283C15490471 @default.
- W1997923283 hasConceptScore W1997923283C170493617 @default.
- W1997923283 hasConceptScore W1997923283C185592680 @default.
- W1997923283 hasConceptScore W1997923283C2775864247 @default.
- W1997923283 hasConceptScore W1997923283C2777785214 @default.
- W1997923283 hasConceptScore W1997923283C2778722691 @default.
- W1997923283 hasConceptScore W1997923283C2780820201 @default.
- W1997923283 hasConceptScore W1997923283C53910766 @default.
- W1997923283 hasConceptScore W1997923283C55493867 @default.
- W1997923283 hasConceptScore W1997923283C71924100 @default.
- W1997923283 hasConceptScore W1997923283C98274493 @default.
- W1997923283 hasIssue "1" @default.
- W1997923283 hasLocation W19979232831 @default.
- W1997923283 hasLocation W19979232832 @default.
- W1997923283 hasOpenAccess W1997923283 @default.
- W1997923283 hasPrimaryLocation W19979232831 @default.
- W1997923283 hasRelatedWork W1979203090 @default.
- W1997923283 hasRelatedWork W1985741820 @default.
- W1997923283 hasRelatedWork W1997923283 @default.
- W1997923283 hasRelatedWork W2000621055 @default.
- W1997923283 hasRelatedWork W2011772285 @default.
- W1997923283 hasRelatedWork W2144268968 @default.
- W1997923283 hasRelatedWork W2730604705 @default.
- W1997923283 hasRelatedWork W4206347286 @default.
- W1997923283 hasRelatedWork W4211075566 @default.
- W1997923283 hasRelatedWork W4233599398 @default.
- W1997923283 hasVolume "432" @default.