FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997925229> ?p ?o ?g. }

• W1997925229 endingPage "1851" @default.
• W1997925229 startingPage "1845" @default.
• W1997925229 abstract "Small-conductance Ca2+ -activated K+ (SK, KCa2) channels are unique in that they are gated solely by changes in intracellular Ca2+ and, hence, function to integrate intracellular Ca2+ and membrane potentials on a beat-to-beat basis. Recent studies have provided evidence for the existence and functional significance of SK channels in the heart. Indeed, our knowledge of cardiac SK channels has been greatly expanded over the past decade. Interests in cardiac SK channels are further driven by recent studies suggesting the critical roles of SK channels in human atrial fibrillation, the SK channel as a possible novel therapeutic target in atrial arrhythmias, and upregulation of SK channels in heart failure in animal models and in human heart failure. However, there remain critical gaps in our knowledge. Specifically, blockade of SK channels in cardiac arrhythmias has been shown to be both antiarrhythmic and proarrhythmic. This contemporary review provides an overview of the literature on the role of cardiac SK channels in cardiac arrhythmias and serves as a discussion platform for the current clinical perspectives. At the translational level, development of SK channel blockers as a new therapeutic strategy in the treatment of atrial fibrillation and the possible proarrhythmic effects merit further considerations and investigations." @default.
• W1997925229 created "2016-06-24" @default.
• W1997925229 creator A5031817215 @default.
• W1997925229 creator A5063257086 @default.
• W1997925229 creator A5077277862 @default.
• W1997925229 date "2015-08-01" @default.
• W1997925229 modified "2023-09-25" @default.
• W1997925229 title "Small-conductance Ca2+-activated K+ channels and cardiac arrhythmias" @default.
• W1997925229 cites W1490915066 @default.
• W1997925229 cites W1537329448 @default.
• W1997925229 cites W1899349190 @default.
• W1997925229 cites W1966824637 @default.
• W1997925229 cites W1971635966 @default.
• W1997925229 cites W1973438087 @default.
• W1997925229 cites W1974676980 @default.
• W1997925229 cites W1979329801 @default.
• W1997925229 cites W1986887981 @default.
• W1997925229 cites W1991890788 @default.
• W1997925229 cites W1992532194 @default.
• W1997925229 cites W1993534871 @default.
• W1997925229 cites W1993838821 @default.
• W1997925229 cites W1998521826 @default.
• W1997925229 cites W2005005085 @default.
• W1997925229 cites W2005555559 @default.
• W1997925229 cites W2006839087 @default.
• W1997925229 cites W2013886538 @default.
• W1997925229 cites W2021566149 @default.
• W1997925229 cites W2030842103 @default.
• W1997925229 cites W2031804346 @default.
• W1997925229 cites W2033948669 @default.
• W1997925229 cites W2036914740 @default.
• W1997925229 cites W2040437516 @default.
• W1997925229 cites W2042670053 @default.
• W1997925229 cites W2051737505 @default.
• W1997925229 cites W2056826664 @default.
• W1997925229 cites W2059821011 @default.
• W1997925229 cites W2061593357 @default.
• W1997925229 cites W2071698136 @default.
• W1997925229 cites W2079788818 @default.
• W1997925229 cites W2081863297 @default.
• W1997925229 cites W2082020713 @default.
• W1997925229 cites W2086163086 @default.
• W1997925229 cites W2086257379 @default.
• W1997925229 cites W2087673585 @default.
• W1997925229 cites W2092426030 @default.
• W1997925229 cites W2093869205 @default.
• W1997925229 cites W2100414478 @default.
• W1997925229 cites W2100904299 @default.
• W1997925229 cites W2113240783 @default.
• W1997925229 cites W2114130324 @default.
• W1997925229 cites W2125058889 @default.
• W1997925229 cites W2126154043 @default.
• W1997925229 cites W2126287329 @default.
• W1997925229 cites W2130348165 @default.
• W1997925229 cites W2134183956 @default.
• W1997925229 cites W2146629694 @default.
• W1997925229 cites W2148204431 @default.
• W1997925229 cites W2148652677 @default.
• W1997925229 cites W2149665587 @default.
• W1997925229 cites W2152124147 @default.
• W1997925229 cites W2152145499 @default.
• W1997925229 cites W2154237611 @default.
• W1997925229 cites W2159441016 @default.
• W1997925229 cites W2160801882 @default.
• W1997925229 cites W2161163873 @default.
• W1997925229 cites W2161645439 @default.
• W1997925229 cites W2330486510 @default.
• W1997925229 cites W2548555003 @default.
• W1997925229 cites W2951870536 @default.
• W1997925229 cites W4250910443 @default.
• W1997925229 doi "https://doi.org/10.1016/j.hrthm.2015.04.046" @default.
• W1997925229 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4662728" @default.
• W1997925229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25956967" @default.
• W1997925229 hasPublicationYear "2015" @default.
• W1997925229 type Work @default.
• W1997925229 sameAs 1997925229 @default.
• W1997925229 citedByCount "57" @default.
• W1997925229 countsByYear W19979252292015 @default.
• W1997925229 countsByYear W19979252292016 @default.
• W1997925229 countsByYear W19979252292017 @default.
• W1997925229 countsByYear W19979252292018 @default.
• W1997925229 countsByYear W19979252292019 @default.
• W1997925229 countsByYear W19979252292020 @default.
• W1997925229 countsByYear W19979252292021 @default.
• W1997925229 countsByYear W19979252292022 @default.
• W1997925229 countsByYear W19979252292023 @default.
• W1997925229 crossrefType "journal-article" @default.
• W1997925229 hasAuthorship W1997925229A5031817215 @default.
• W1997925229 hasAuthorship W1997925229A5063257086 @default.
• W1997925229 hasAuthorship W1997925229A5077277862 @default.
• W1997925229 hasBestOaLocation W19979252292 @default.
• W1997925229 hasConcept C126322002 @default.
• W1997925229 hasConcept C15744967 @default.
• W1997925229 hasConcept C164705383 @default.
• W1997925229 hasConcept C169760540 @default.
• W1997925229 hasConcept C2778198053 @default.
• W1997925229 hasConcept C2779161974 @default.
• W1997925229 hasConcept C2910096629 @default.

• next