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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997930109> ?p ?o ?g. }

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• W1997930109 abstract "Efforts were dedicated to develop potent and brain penetrant prolylcarboxypeptidase (PrCP) inhibitors by replacing the amide group of original leads 1 and 2 with heterocycles. Aminopyrimidines including compound 32a were identified to display good PrCP inhibitory activity (32a, IC50 = 43 nM) and impressive ability to penetrate brain in mice (brain/plasma ratio: 1.4)." @default.
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• W1997930109 date "2012-02-01" @default.
• W1997930109 modified "2023-09-26" @default.
• W1997930109 title "Discovery of aminoheterocycles as potent and brain penetrant prolylcarboxypeptidase inhibitors" @default.
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• W1997930109 doi "https://doi.org/10.1016/j.bmcl.2011.12.098" @default.
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