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- W1997934385 abstract "Abstract. The effect of accelerating the clearance rate of isologous erythrocytes on the immune response to antigens present on the erythrocytes was studied in rabbits. HgA negative rabbits injected with 80 μg anti-HgA antibody 5 h before challenge with HgA positive erythrocytes cleared these erythrocytes significantly faster than controls and their anti-HgA antibody response was suppressed as compared with controls. Rabbits injected with heated erythrocytes (49°C for 10 min) or given 350 μg anti-HgA antibody 3 months before challenge cleared the donor erythrocytes even faster. Despite this their anti-HgA antibody response was not significantly suppressed as compared with controls. It is considered that in the HgA system the prime factor causing immunosuppression by IgG iso-antibody is competition for antigenic determinants by passive antibody with antibody-like receptors on antigen sensitive cells and that a similar mechanism is responsible for the prevention of Rh isoimmunisation by anti-D antibody." @default.
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- W1997934385 date "1971-03-01" @default.
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- W1997934385 title "Clearance of Erythrocytes and the Immune Response An Experimental Study" @default.
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- W1997934385 doi "https://doi.org/10.1111/j.1423-0410.1971.tb00431.x" @default.
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