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- W1997937292 abstract "The effects of pH and hexachlorophene on the net fixed-charge density of the colloids composing the epidermal surface were studied in vivo employing human subjects. The results are analogous to titration curves of amphoteric macromolecules. The study was performed over a pH range of 1.1-12.3 in the presence and absence of saturated concentrations of hexachlorophene. Both the control and hexachlorophene titration curves were nonhysteretic when initiated at either extreme of the pH range; this finding indicates reversibility of the observed pH and hexachlorophene-induced changes. The presence of hexachlorophene decreased the net fixed-charge density of the tissue surface below pH 5.6. Above pH 5.6, a net increase was consistently observed. Mechanistically, the hexachlorophene-induced alterations in fixed-charge density are hypothesized as resulting from allosterically effected changes in the dissociation constants of ionogenic protein side groups located vicinally to hexachlorophene interaction sites. The bioelectrometric method allowed the study to be performed without causing any injury or discomfort to the subjects. The results of the present study suggest a further utility for the bioelectrometic method in studies of the substantive antibacterial behavior of hexachlorophene on human skin." @default.
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- W1997937292 date "1970-10-01" @default.
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- W1997937292 title "Interaction of Hexachlorophene with Human Epidermis I: In Vivo Bioelectrometric Study of Ph Influence" @default.
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- W1997937292 doi "https://doi.org/10.1002/jps.2600591019" @default.
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