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- W1997940644 abstract "Migration of Rana temporaria peritoneal exudate cells (PEC) was examined in vitro using both direct and indirect assay systems. After sensitization in vivo followed by in vitro challenge 7-21 days later with the appropriate sensitizing antigen, spleen cell culture supernatants were obtained which inhibited the normal in vitro migration of PEC from non-sensitized animals. Cultures of spleen cells with mitogen also gave rise to supernatants with migration inhibitory properties. Sephadex separation of supernatants showed that maximum inhibitory activity was present in the 27-50,000 MW range and, furthermore, that this inhibition was blocked by alpha-L-fucose, but not by beta-D-galactose. The inhibition did not appear to be species specific. The results indicate that following appropriate stimulation amphibian leucocytes produce a soluble, migration inhibition factor (MIF) with characteristics similar to those described for the mammalian lymphokine MIF." @default.
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- W1997940644 date "1985-03-01" @default.
- W1997940644 modified "2023-09-24" @default.
- W1997940644 title "Amphibian lymphokines: 2 Migration inhibition factor produced by antigenic and mitogenic stimulation of amphibian leucocytes" @default.
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- W1997940644 doi "https://doi.org/10.1016/0145-305x(85)90120-x" @default.
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