FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997940963> ?p ?o ?g. }

• W1997940963 endingPage "259" @default.
• W1997940963 startingPage "249" @default.
• W1997940963 abstract "Sublines of the lactogen-dependent, rat pre-T Nb2 lymphoma are useful as a model for the investigation of prolactin (PRL) signaling mechanisms, regulation of transcription of target genes, and the immunomodulatory and anti-apoptotic actions of the hormone in T lymphocytes. In the present study, coupling of various tyrosine, serine/threonine, and phospholipid kinase signaling mechanisms to PRL-stimulated Nb2-11 cell proliferation and expression of the protooncogene, pim-1, was investigated utilizing pharmacologic antagonists of a broad spectrum of tyrosine kinases (tyrphostin A25), and the specific enzymes, Jak2 (tyrphostin B42) and ZAP-70 (piceatannol), as well as mitogen-activated protein kinase (MAPK, PD98059), protein kinase C (PKC, calphostin C), and phosphatidylinositol 3-kinase (PI3-kinase, LY294002). Inhibition of each pathway attenuated PRL-stimulated Nb2-11 cell proliferation in a concentration-dependent manner. Blockade of MAPK was the least efficacious; it inhibited proliferation maximally by 60%. Northern blot analysis of pim-1 expression in antagonist-treated cells revealed that MAPK, Jak2 and PI3-kinase appeared to signal to initiation of pim-1 transcription; its expression was attenuated by each of the antagonists. In other experiments, PRL was shown to rapidly activate a downstream effector of PI3-kinase, Akt, and this effect was also blocked by LY294002. It is concluded that PRL-stimulated Nb2 cell proliferation requires participation of each of the signaling pathways investigated. Moreover, hormone-mediated expression of pim-1 appears to reflect signaling by MAPK, Jak2, and PI3-kinase." @default.
• W1997940963 created "2016-06-24" @default.
• W1997940963 creator A5035949192 @default.
• W1997940963 creator A5063737259 @default.
• W1997940963 creator A5076354524 @default.
• W1997940963 creator A5087899903 @default.
• W1997940963 date "2001-02-01" @default.
• W1997940963 modified "2023-09-23" @default.
• W1997940963 title "Prolactin signaling to pim-1 expression: a role for phosphatidylinositol 3-kinase" @default.
• W1997940963 cites W1484122498 @default.
• W1997940963 cites W1758311809 @default.
• W1997940963 cites W1884801295 @default.
• W1997940963 cites W1942718916 @default.
• W1997940963 cites W1965127835 @default.
• W1997940963 cites W1971915141 @default.
• W1997940963 cites W1980340355 @default.
• W1997940963 cites W1998002970 @default.
• W1997940963 cites W2003543806 @default.
• W1997940963 cites W2009323734 @default.
• W1997940963 cites W2014669590 @default.
• W1997940963 cites W2014857399 @default.
• W1997940963 cites W2017515991 @default.
• W1997940963 cites W2030573603 @default.
• W1997940963 cites W2034442000 @default.
• W1997940963 cites W2038553733 @default.
• W1997940963 cites W2041049358 @default.
• W1997940963 cites W2043542949 @default.
• W1997940963 cites W2046754207 @default.
• W1997940963 cites W2047826668 @default.
• W1997940963 cites W2053915802 @default.
• W1997940963 cites W2056372266 @default.
• W1997940963 cites W2057126133 @default.
• W1997940963 cites W2064432291 @default.
• W1997940963 cites W2076469466 @default.
• W1997940963 cites W2089523203 @default.
• W1997940963 cites W2089751246 @default.
• W1997940963 cites W2091159641 @default.
• W1997940963 cites W2094159867 @default.
• W1997940963 cites W2096176273 @default.
• W1997940963 cites W2097767970 @default.
• W1997940963 cites W2108664888 @default.
• W1997940963 cites W2127048642 @default.
• W1997940963 cites W2128201530 @default.
• W1997940963 cites W2168645089 @default.
• W1997940963 cites W2169823880 @default.
• W1997940963 cites W2312200375 @default.
• W1997940963 cites W2316854744 @default.
• W1997940963 cites W2332632815 @default.
• W1997940963 cites W2576734941 @default.
• W1997940963 cites W344789099 @default.
• W1997940963 cites W4229490916 @default.
• W1997940963 cites W4229760646 @default.
• W1997940963 cites W4232353822 @default.
• W1997940963 cites W4232721404 @default.
• W1997940963 cites W4234457673 @default.
• W1997940963 cites W4234852508 @default.
• W1997940963 cites W4239142818 @default.
• W1997940963 cites W4239708564 @default.
• W1997940963 cites W4240309555 @default.
• W1997940963 cites W4241536334 @default.
• W1997940963 cites W4243049900 @default.
• W1997940963 cites W4255539559 @default.
• W1997940963 cites W4553897 @default.
• W1997940963 doi "https://doi.org/10.1016/s0165-5728(00)00430-6" @default.
• W1997940963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11164909" @default.
• W1997940963 hasPublicationYear "2001" @default.
• W1997940963 type Work @default.
• W1997940963 sameAs 1997940963 @default.
• W1997940963 citedByCount "23" @default.
• W1997940963 countsByYear W19979409632012 @default.
• W1997940963 countsByYear W19979409632013 @default.
• W1997940963 countsByYear W19979409632017 @default.
• W1997940963 crossrefType "journal-article" @default.
• W1997940963 hasAuthorship W1997940963A5035949192 @default.
• W1997940963 hasAuthorship W1997940963A5063737259 @default.
• W1997940963 hasAuthorship W1997940963A5076354524 @default.
• W1997940963 hasAuthorship W1997940963A5087899903 @default.
• W1997940963 hasConcept C137361374 @default.
• W1997940963 hasConcept C184235292 @default.
• W1997940963 hasConcept C2776912716 @default.
• W1997940963 hasConcept C2778308172 @default.
• W1997940963 hasConcept C2780610907 @default.
• W1997940963 hasConcept C2909378205 @default.
• W1997940963 hasConcept C42362537 @default.
• W1997940963 hasConcept C57074206 @default.
• W1997940963 hasConcept C62478195 @default.
• W1997940963 hasConcept C75217442 @default.
• W1997940963 hasConcept C86554907 @default.
• W1997940963 hasConcept C86803240 @default.
• W1997940963 hasConcept C95444343 @default.
• W1997940963 hasConcept C97029542 @default.
• W1997940963 hasConceptScore W1997940963C137361374 @default.
• W1997940963 hasConceptScore W1997940963C184235292 @default.
• W1997940963 hasConceptScore W1997940963C2776912716 @default.
• W1997940963 hasConceptScore W1997940963C2778308172 @default.
• W1997940963 hasConceptScore W1997940963C2780610907 @default.
• W1997940963 hasConceptScore W1997940963C2909378205 @default.
• W1997940963 hasConceptScore W1997940963C42362537 @default.

• next