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• W1997942715 abstract "Interleukin (IL)-2 promotes regulatory T-cell development and function, and treatment with IL-2 is being tested as therapy for some autoimmune diseases. However, patients receiving IL-2 treatment also experience eosinophilia due to an unknown mechanism. Here, we show that patients receiving low-dose IL-2 have elevated levels of serum IL-5, and this correlates with their degree of eosinophilia. In mice, low-dose IL-2-anti-IL-2 antibody complexes drove group 2 innate lymphoid cells (ILC2) to produce IL-5 and proliferate. Using genetic approaches in mice, we demonstrate that activation of ILC2 was responsible for the eosinophilia observed with IL-2 therapy. These observations reveal a novel cellular network that is activated during IL-2 treatment. A better understanding of the cross talk between these cell populations may lead to more effective targeting of IL-2 to treat autoimmune disease." @default.
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• W1997942715 date "2014-12-04" @default.
• W1997942715 modified "2023-10-18" @default.
• W1997942715 title "Interleukin-5–producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy" @default.
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• W1997942715 doi "https://doi.org/10.1182/blood-2014-07-587493" @default.
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