FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997946337> ?p ?o ?g. }

• W1997946337 endingPage "830" @default.
• W1997946337 startingPage "825" @default.
• W1997946337 abstract "A regimen consisting of antilymphocyte serum (ALS), sirolimus, and donor bone-marrow-cell (BMC) infusion induces indefinite skin allograft survival across fully mismatched mouse strain combinations. We investigated the role of chimerism in this transplantation tolerance model.B10.A (H-2a) mice were treated with ALS on day -1 and 2, sirolimus, and infusion of (C57BL/6xDBA/2)F1 (B6D2F1, H-2(b/d)) BMCs on day 7 relative to DBA/2 (D2) skin grafting on day 0. At postgraft days 30, 50 and 120, the recipient mice were injected intravenously with splenocytes prepared from either naive or D2 mixed chimeric B10.A mice that had been sensitized in vivo to B6. Changes in chimerism and graft survival were monitored.Although D2 skin grafts were rejected with a median survival time of 63.8 days in B10.A mice given ALS and sirolimus alone, they survived more than 200 days in all B10.A mice given ALS, sirolimus, and B6D2F1 BMCs. Chimerism became evident 21 days postgrafting and progressively increased thereafter to 20% at postgraft day 200. Infusion of anti-B6 presensitized cells resulted in depletion of chimeric donor cells and subsequent graft rejection regardless of the timing of injection. Injection of presensitized cells in mice given ALS and sirolimus alone had no effect on graft survival. Injection of presensitized cells that were cytotoxic to alloantigen expressed by BMCs but tolerant to skin reduced, but did not deplete, established chimerism and allowed continued allograft survival.Chimeric donor cells play a major role in both the early and late phases of transplantation tolerance induced by the ALS, sirolimus, and BMC regimen." @default.
• W1997946337 created "2016-06-24" @default.
• W1997946337 creator A5001917875 @default.
• W1997946337 creator A5038938677 @default.
• W1997946337 creator A5047141592 @default.
• W1997946337 date "2004-09-27" @default.
• W1997946337 modified "2023-10-14" @default.
• W1997946337 title "Active Role of Chimerism in Transplantation Tolerance Induced by Antilymphocyte Serum, Sirolimus, and Bone–Marrow-Cell Infusion" @default.
• W1997946337 cites W1508908703 @default.
• W1997946337 cites W1596952458 @default.
• W1997946337 cites W1599651003 @default.
• W1997946337 cites W1929691604 @default.
• W1997946337 cites W2028267771 @default.
• W1997946337 cites W2040775375 @default.
• W1997946337 cites W2044317644 @default.
• W1997946337 cites W2114933778 @default.
• W1997946337 cites W2132243512 @default.
• W1997946337 cites W2152918507 @default.
• W1997946337 cites W2159228497 @default.
• W1997946337 cites W4313376908 @default.
• W1997946337 doi "https://doi.org/10.1097/01.tp.0000135463.21290.6b" @default.
• W1997946337 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15385800" @default.
• W1997946337 hasPublicationYear "2004" @default.
• W1997946337 type Work @default.
• W1997946337 sameAs 1997946337 @default.
• W1997946337 citedByCount "8" @default.
• W1997946337 countsByYear W19979463372012 @default.
• W1997946337 countsByYear W19979463372013 @default.
• W1997946337 countsByYear W19979463372015 @default.
• W1997946337 crossrefType "journal-article" @default.
• W1997946337 hasAuthorship W1997946337A5001917875 @default.
• W1997946337 hasAuthorship W1997946337A5038938677 @default.
• W1997946337 hasAuthorship W1997946337A5047141592 @default.
• W1997946337 hasBestOaLocation W19979463371 @default.
• W1997946337 hasConcept C104317684 @default.
• W1997946337 hasConcept C109159458 @default.
• W1997946337 hasConcept C126322002 @default.
• W1997946337 hasConcept C154317977 @default.
• W1997946337 hasConcept C16685009 @default.
• W1997946337 hasConcept C189976730 @default.
• W1997946337 hasConcept C202751555 @default.
• W1997946337 hasConcept C203014093 @default.
• W1997946337 hasConcept C2777702733 @default.
• W1997946337 hasConcept C2777921159 @default.
• W1997946337 hasConcept C2777928079 @default.
• W1997946337 hasConcept C2780007613 @default.
• W1997946337 hasConcept C2780931953 @default.
• W1997946337 hasConcept C28328180 @default.
• W1997946337 hasConcept C2908554679 @default.
• W1997946337 hasConcept C2911091166 @default.
• W1997946337 hasConcept C2993713153 @default.
• W1997946337 hasConcept C30278631 @default.
• W1997946337 hasConcept C54355233 @default.
• W1997946337 hasConcept C55493867 @default.
• W1997946337 hasConcept C71924100 @default.
• W1997946337 hasConcept C86803240 @default.
• W1997946337 hasConcept C8891405 @default.
• W1997946337 hasConcept C98274493 @default.
• W1997946337 hasConceptScore W1997946337C104317684 @default.
• W1997946337 hasConceptScore W1997946337C109159458 @default.
• W1997946337 hasConceptScore W1997946337C126322002 @default.
• W1997946337 hasConceptScore W1997946337C154317977 @default.
• W1997946337 hasConceptScore W1997946337C16685009 @default.
• W1997946337 hasConceptScore W1997946337C189976730 @default.
• W1997946337 hasConceptScore W1997946337C202751555 @default.
• W1997946337 hasConceptScore W1997946337C203014093 @default.
• W1997946337 hasConceptScore W1997946337C2777702733 @default.
• W1997946337 hasConceptScore W1997946337C2777921159 @default.
• W1997946337 hasConceptScore W1997946337C2777928079 @default.
• W1997946337 hasConceptScore W1997946337C2780007613 @default.
• W1997946337 hasConceptScore W1997946337C2780931953 @default.
• W1997946337 hasConceptScore W1997946337C28328180 @default.
• W1997946337 hasConceptScore W1997946337C2908554679 @default.
• W1997946337 hasConceptScore W1997946337C2911091166 @default.
• W1997946337 hasConceptScore W1997946337C2993713153 @default.
• W1997946337 hasConceptScore W1997946337C30278631 @default.
• W1997946337 hasConceptScore W1997946337C54355233 @default.
• W1997946337 hasConceptScore W1997946337C55493867 @default.
• W1997946337 hasConceptScore W1997946337C71924100 @default.
• W1997946337 hasConceptScore W1997946337C86803240 @default.
• W1997946337 hasConceptScore W1997946337C8891405 @default.
• W1997946337 hasConceptScore W1997946337C98274493 @default.
• W1997946337 hasIssue "6" @default.
• W1997946337 hasLocation W19979463371 @default.
• W1997946337 hasLocation W19979463372 @default.
• W1997946337 hasOpenAccess W1997946337 @default.
• W1997946337 hasPrimaryLocation W19979463371 @default.
• W1997946337 hasRelatedWork W1914574530 @default.
• W1997946337 hasRelatedWork W1967340697 @default.
• W1997946337 hasRelatedWork W1997946337 @default.
• W1997946337 hasRelatedWork W2007075846 @default.
• W1997946337 hasRelatedWork W2018722307 @default.
• W1997946337 hasRelatedWork W2019959386 @default.
• W1997946337 hasRelatedWork W2027283859 @default.
• W1997946337 hasRelatedWork W2065897280 @default.
• W1997946337 hasRelatedWork W2328257317 @default.
• W1997946337 hasRelatedWork W2400740345 @default.
• W1997946337 hasVolume "78" @default.

• next