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- W1997948093 abstract "The phagocytic NADPH oxidase is recognized as a critical component of innate immunity, responsible for generation of microbicidal reactive oxygen species (ROS). This enzyme is one representative of the Nox family of oxidases (Nox1–Nox5, Duox1, and Duox2) that exhibit diverse expression patterns and appear to serve a variety of functions related to ROS generation. Mounting evidence now suggests that several of these novel oxidases also serve in host defense, particularly those showing high expression along epithelial surfaces exposed to the external environment. Within these sites, Nox enzymes tend to be located on apical cell surfaces and release ROS into extracellular environments, where they can be used by known antimicrobial peroxidases. Moreover, microbial factors were shown in several cases to cause higher ROS production, either by direct oxidase activation or by inducing higher oxidase expression. Several oxidases are also induced by immune cytokines, including interferon-γ, interleukin (IL)-4, and IL-13. Although most of the evidence supporting host defense roles for mammalian nonphagocytic oxidases remains circumstantial, recent evidence indicates that Drosophila Duox plays a role in host resistance to infection. Finally, oxidative defense against invading pathogens appears to be an ancient protective mechanism, because related oxidases are known to participate in disease resistance in plants." @default.
- W1997948093 created "2016-06-24" @default.
- W1997948093 creator A5051880377 @default.
- W1997948093 creator A5087116887 @default.
- W1997948093 date "2006-09-01" @default.
- W1997948093 modified "2023-10-11" @default.
- W1997948093 title "Role of Nox Family NADPH Oxidases in Host Defense" @default.
- W1997948093 cites W1520628059 @default.
- W1997948093 cites W1558940004 @default.
- W1997948093 cites W1585390661 @default.
- W1997948093 cites W1602489512 @default.
- W1997948093 cites W1840788329 @default.
- W1997948093 cites W1968860507 @default.
- W1997948093 cites W1971215115 @default.
- W1997948093 cites W1972641293 @default.
- W1997948093 cites W1972987064 @default.
- W1997948093 cites W1974340628 @default.
- W1997948093 cites W1976040793 @default.
- W1997948093 cites W1977378846 @default.
- W1997948093 cites W1978979107 @default.
- W1997948093 cites W1981921279 @default.
- W1997948093 cites W1983229253 @default.
- W1997948093 cites W1986099097 @default.
- W1997948093 cites W1989622726 @default.
- W1997948093 cites W1991281501 @default.
- W1997948093 cites W1995247596 @default.
- W1997948093 cites W2000079184 @default.
- W1997948093 cites W2000754365 @default.
- W1997948093 cites W2001946904 @default.
- W1997948093 cites W2003241255 @default.
- W1997948093 cites W2008149338 @default.
- W1997948093 cites W2008981570 @default.
- W1997948093 cites W2010630254 @default.
- W1997948093 cites W2011062898 @default.
- W1997948093 cites W2011082117 @default.
- W1997948093 cites W2014124696 @default.
- W1997948093 cites W2014944893 @default.
- W1997948093 cites W2017443683 @default.
- W1997948093 cites W2020319663 @default.
- W1997948093 cites W2022385815 @default.
- W1997948093 cites W2026729610 @default.
- W1997948093 cites W2036811549 @default.
- W1997948093 cites W2037854342 @default.
- W1997948093 cites W2038492783 @default.
- W1997948093 cites W2045015262 @default.
- W1997948093 cites W2045973396 @default.
- W1997948093 cites W2048486951 @default.
- W1997948093 cites W2049352189 @default.
- W1997948093 cites W2057397798 @default.
- W1997948093 cites W2058989790 @default.
- W1997948093 cites W2059971395 @default.
- W1997948093 cites W2063258491 @default.
- W1997948093 cites W2063958461 @default.
- W1997948093 cites W2064358616 @default.
- W1997948093 cites W2064820057 @default.
- W1997948093 cites W2067068055 @default.
- W1997948093 cites W2067238205 @default.
- W1997948093 cites W2071919212 @default.
- W1997948093 cites W2072174276 @default.
- W1997948093 cites W2073241455 @default.
- W1997948093 cites W2073393551 @default.
- W1997948093 cites W2075084323 @default.
- W1997948093 cites W2075238900 @default.
- W1997948093 cites W2079228647 @default.
- W1997948093 cites W2079639127 @default.
- W1997948093 cites W2079682797 @default.
- W1997948093 cites W2084699108 @default.
- W1997948093 cites W2084814184 @default.
- W1997948093 cites W2087357919 @default.
- W1997948093 cites W2089887078 @default.
- W1997948093 cites W2096901938 @default.
- W1997948093 cites W2098616253 @default.
- W1997948093 cites W2101692904 @default.
- W1997948093 cites W2101745219 @default.
- W1997948093 cites W2102538853 @default.
- W1997948093 cites W2102619095 @default.
- W1997948093 cites W2103326429 @default.
- W1997948093 cites W2105940831 @default.
- W1997948093 cites W2108235369 @default.
- W1997948093 cites W2115239727 @default.
- W1997948093 cites W2115755375 @default.
- W1997948093 cites W2116837665 @default.
- W1997948093 cites W2118994238 @default.
- W1997948093 cites W2122156976 @default.
- W1997948093 cites W2124566107 @default.
- W1997948093 cites W2126973445 @default.
- W1997948093 cites W2136261717 @default.
- W1997948093 cites W2138396364 @default.
- W1997948093 cites W2144795074 @default.
- W1997948093 cites W2145369410 @default.
- W1997948093 cites W2150264174 @default.
- W1997948093 cites W2150277507 @default.
- W1997948093 cites W2150591923 @default.
- W1997948093 cites W2154741999 @default.
- W1997948093 cites W2155083127 @default.
- W1997948093 cites W2158875146 @default.
- W1997948093 cites W2159127121 @default.
- W1997948093 cites W2161615911 @default.