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- W1997951359 abstract "BackgroundPseudomonas aeruginosa airway infection is associated with a high mortality rate in cystic fibrosis. Lipopolysaccharide (LPS), a main constituent of the outer membrane of P. aeruginosa, is responsible for activation of innate immune response but its role on airway epithelium ion transport, is not well known. The aim of this study was to determine the role for P. aeruginosa LPS in modulating chloride secretion and intracellular calcium in the human bronchial epithelial cell line, 16HBE14o−.MethodsWe used intracellular calcium imaging and short-circuit current measurement upon exposure of cells to P. aeruginosa LPS.ResultsApical LPS stimulated intracellular calcium release and calcium entry and enhanced chloride secretion. This latter effect was significantly inhibited by CFTR(inh)-172 and BAPTA-AM (intracellular Ca2+ chelator).ConclusionsOur data provides evidence for a new role of P. aeruginosa LPS in stimulating calcium entry and release and a subsequent chloride secretion via CFTR in human bronchial epithelium." @default.
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- W1997951359 date "2013-01-01" @default.
- W1997951359 modified "2023-10-18" @default.
- W1997951359 title "P. aeruginosa LPS stimulates calcium signaling and chloride secretion via CFTR in human bronchial epithelial cells" @default.
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- W1997951359 doi "https://doi.org/10.1016/j.jcf.2012.06.007" @default.
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