Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997955768> ?p ?o ?g. }
- W1997955768 endingPage "103" @default.
- W1997955768 startingPage "1" @default.
- W1997955768 abstract "Respiratory tract fluid, produced from an enormous area spanning the mucosa of the nose to the alveolar surface, is a complex mixture of serum transudate and locally secreted proteins and glycomucoproteins and of inflammatory and immune effector cells intermingled. Its analysis is important in understanding the pathogenesis of respiratory diseases and remains essential for the clinical diagnosis of most lung disorders. Many basic facts about the formation and composition of this fluid remain unknown, and little information exists about absorptive mechanisms along the airways. Respiratory fluid is not homogeneous but has unique regional characteristics that are becoming better appreciated as more selective sampling methods are devised. Above all, it is a dynamic substance in healthy airways and diseased ones, and any specimen is just a point-in-time sample that can change in composition, often making serial analysis and comparisons necessary. Nasal fluids currently have limited diagnostic application except in allergic rhinitis. Expectorant (sputum) telescopes fluid and cells from all areas and is not from a specific locale, so the trend is to retrieve more selective and regional specimens of airways fluids. Technology largely does not exist to collect area specimens, except for bronchoalveolar lavage, which generally samples the alveolar surface. Clearly, bronchoalveolar lavage fluid analysis has been the favored way to characterize the peripheral air-spaces for the past 10 years or so, and most of this monograph has been devoted to normal data derived from lavage specimens and to a few examples of lung disease that reflect this burgeoning application. In many respects, results obtained from lavage fluid are virtually in catalogue form at present, and it remains to the future to know how some of the observations will help make diagnosis better or elucidate pathogenic mechanisms. Generally, bronchoalveolar lavage fluid analysis has led to better concepts of immunopathology of many diseases and provided new ways to monitor the evolution of certain diseases, especially the diffuse interstitial lung disorders, but development of specific criteria for diagnosis has been less rewarding. However, certain patterns of lymphocyte-predominant alveolitis, suggesting sarcoidosis or hypersensitivity diseases, recognition of specific T lymphocyte defects and opportunistic microorganisms as in AIDS, and the use of microprobe electron analysis to identify cellular particulates all point to more precision of diagnosis. Alveolar proteinosis and histiocytosis X may be detected from lavage fluid components. The prospects are truly exciting.(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
- W1997955768 created "2016-06-24" @default.
- W1997955768 creator A5043930897 @default.
- W1997955768 creator A5071829879 @default.
- W1997955768 date "1984-02-01" @default.
- W1997955768 modified "2023-09-30" @default.
- W1997955768 title "Respiratory tract fluids: Analysis of content and contemporary use in understanding lung diseases" @default.
- W1997955768 cites W1487146832 @default.
- W1997955768 cites W1695953090 @default.
- W1997955768 cites W1757031429 @default.
- W1997955768 cites W1764687875 @default.
- W1997955768 cites W1969542526 @default.
- W1997955768 cites W1970176527 @default.
- W1997955768 cites W1971261709 @default.
- W1997955768 cites W1971974464 @default.
- W1997955768 cites W1976054267 @default.
- W1997955768 cites W1982389776 @default.
- W1997955768 cites W1984640795 @default.
- W1997955768 cites W1986283478 @default.
- W1997955768 cites W1987450381 @default.
- W1997955768 cites W1990866772 @default.
- W1997955768 cites W1995032318 @default.
- W1997955768 cites W1996755778 @default.
- W1997955768 cites W1996788187 @default.
- W1997955768 cites W2002581726 @default.
- W1997955768 cites W2002983094 @default.
- W1997955768 cites W2007461942 @default.
- W1997955768 cites W2009076307 @default.
- W1997955768 cites W2012412421 @default.
- W1997955768 cites W2012652405 @default.
- W1997955768 cites W2013674196 @default.
- W1997955768 cites W2018325697 @default.
- W1997955768 cites W2026735496 @default.
- W1997955768 cites W2028213575 @default.
- W1997955768 cites W2035383948 @default.
- W1997955768 cites W2037459166 @default.
- W1997955768 cites W2039490835 @default.
- W1997955768 cites W2042467899 @default.
- W1997955768 cites W2042949902 @default.
- W1997955768 cites W2043068531 @default.
- W1997955768 cites W2047621648 @default.
- W1997955768 cites W2049638816 @default.
- W1997955768 cites W2051555638 @default.
- W1997955768 cites W2051800344 @default.
- W1997955768 cites W2052722632 @default.
- W1997955768 cites W2054273225 @default.
- W1997955768 cites W2061053512 @default.
- W1997955768 cites W2064100897 @default.
- W1997955768 cites W2066367045 @default.
- W1997955768 cites W2068948874 @default.
- W1997955768 cites W2069645726 @default.
- W1997955768 cites W2070454645 @default.
- W1997955768 cites W2072654368 @default.
- W1997955768 cites W2074619959 @default.
- W1997955768 cites W2074760059 @default.
- W1997955768 cites W2076940976 @default.
- W1997955768 cites W2078347909 @default.
- W1997955768 cites W2078571876 @default.
- W1997955768 cites W2079887533 @default.
- W1997955768 cites W2083539124 @default.
- W1997955768 cites W2085232829 @default.
- W1997955768 cites W2088487331 @default.
- W1997955768 cites W2088899261 @default.
- W1997955768 cites W2090700732 @default.
- W1997955768 cites W2090763136 @default.
- W1997955768 cites W2092564170 @default.
- W1997955768 cites W2093039976 @default.
- W1997955768 cites W2097596146 @default.
- W1997955768 cites W2101080746 @default.
- W1997955768 cites W2105722261 @default.
- W1997955768 cites W2106348710 @default.
- W1997955768 cites W2113257020 @default.
- W1997955768 cites W2122359262 @default.
- W1997955768 cites W2130324642 @default.
- W1997955768 cites W2131028193 @default.
- W1997955768 cites W2134967918 @default.
- W1997955768 cites W2158228818 @default.
- W1997955768 cites W2162202615 @default.
- W1997955768 cites W2164618329 @default.
- W1997955768 cites W2170470270 @default.
- W1997955768 cites W2216115311 @default.
- W1997955768 cites W2275545763 @default.
- W1997955768 cites W2314963017 @default.
- W1997955768 cites W2316436656 @default.
- W1997955768 cites W2323098333 @default.
- W1997955768 cites W2323254689 @default.
- W1997955768 cites W2327135847 @default.
- W1997955768 cites W2328959700 @default.
- W1997955768 cites W2331476834 @default.
- W1997955768 cites W2337037958 @default.
- W1997955768 cites W2342357083 @default.
- W1997955768 cites W2344188092 @default.
- W1997955768 cites W2408053553 @default.
- W1997955768 cites W2414632349 @default.
- W1997955768 cites W2415428410 @default.
- W1997955768 cites W2418727743 @default.
- W1997955768 cites W2435206497 @default.
- W1997955768 cites W2594294830 @default.