FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997965099> ?p ?o ?g. }

• W1997965099 endingPage "4138" @default.
• W1997965099 startingPage "4130" @default.
• W1997965099 abstract "Abstract Purpose: It has been suggested that cysteine-rich secretory protein 3 (CRISP-3) and β-microseminoprotein (MSP) are associated with outcome in prostate cancer. We investigated whether these markers are related to biochemical recurrence and whether addition of the markers improves prediction of recurring disease. Experimental Design: Tissue microarrays of radical prostatectomy specimens were analyzed for CRISP-3 and MSP by immunohistochemistry. Associations between marker positivity and postprostatectomy biochemical recurrence [prostate-specific antigen (PSA) &gt;0.2 ng/mL with a confirmatory level] were evaluated by univariate and multivariable Cox proportional hazards regression. Multivariable analyses controlled for preoperative PSA and pathologic stage and grade. Results: Among 945 patients, 224 had recurrence. Median follow-up for survivors was 6.0 years. Patients positive for CRISP-3 had smaller recurrence-free probabilities, whereas MSP-positive patients had larger recurrence-free probabilities. On univariate analysis, the hazard ratio for patients positive versus negative for CRISP-3 was 1.53 (P = 0.010) and for MSP was 0.63 (P = 0.004). On multivariable analysis, both CRISP-3 (P = 0.007) and MSP (P = 0.002) were associated with recurrence. The hazard ratio among CRISP-3–positive/MSP-negative patients compared with CRISP-3–negative/MSP-positive patients was 2.38. Adding CRISP-3 to a base model that included PSA and pathologic stage and grade did not enhance the prediction of recurrence, but adding MSP increased the concordance index minimally from 0.778 to 0.781. Conclusion: We report evidence that CRISP-3 and MSP are independent predictors of recurrence after radical prostatectomy for localized prostate cancer. However, addition of the markers does not importantly improve the performance of existing predictive models. Further research should aim to elucidate the functions of CRISP-3 and MSP in prostate cancer cells." @default.
• W1997965099 created "2016-06-24" @default.
• W1997965099 creator A5000166823 @default.
• W1997965099 creator A5010536553 @default.
• W1997965099 creator A5012224683 @default.
• W1997965099 creator A5015634061 @default.
• W1997965099 creator A5020234995 @default.
• W1997965099 creator A5022477189 @default.
• W1997965099 creator A5030594142 @default.
• W1997965099 creator A5052299820 @default.
• W1997965099 creator A5056770711 @default.
• W1997965099 creator A5057040034 @default.
• W1997965099 creator A5067230136 @default.
• W1997965099 creator A5078841695 @default.
• W1997965099 date "2007-07-15" @default.
• W1997965099 modified "2023-10-18" @default.
• W1997965099 title "Association of Cysteine-Rich Secretory Protein 3 and β-Microseminoprotein with Outcome after Radical Prostatectomy" @default.
• W1997965099 cites W1571917377 @default.
• W1997965099 cites W1601826601 @default.
• W1997965099 cites W1605638342 @default.
• W1997965099 cites W1819910556 @default.
• W1997965099 cites W1871924278 @default.
• W1997965099 cites W1932417500 @default.
• W1997965099 cites W1963592300 @default.
• W1997965099 cites W1964043391 @default.
• W1997965099 cites W1967788599 @default.
• W1997965099 cites W1970018641 @default.
• W1997965099 cites W1971207545 @default.
• W1997965099 cites W1979693703 @default.
• W1997965099 cites W1980633528 @default.
• W1997965099 cites W1988336550 @default.
• W1997965099 cites W1990672165 @default.
• W1997965099 cites W1997581710 @default.
• W1997965099 cites W2001675134 @default.
• W1997965099 cites W2009364828 @default.
• W1997965099 cites W2013713901 @default.
• W1997965099 cites W2015673321 @default.
• W1997965099 cites W2018235438 @default.
• W1997965099 cites W2028853380 @default.
• W1997965099 cites W2029628988 @default.
• W1997965099 cites W2035777674 @default.
• W1997965099 cites W2036902495 @default.
• W1997965099 cites W2038981894 @default.
• W1997965099 cites W2049525334 @default.
• W1997965099 cites W2060860221 @default.
• W1997965099 cites W2080071903 @default.
• W1997965099 cites W2086514248 @default.
• W1997965099 cites W2087810003 @default.
• W1997965099 cites W2089017800 @default.
• W1997965099 cites W2100001148 @default.
• W1997965099 cites W2108607239 @default.
• W1997965099 cites W2109600639 @default.
• W1997965099 cites W2112601799 @default.
• W1997965099 cites W2129122136 @default.
• W1997965099 cites W2133069875 @default.
• W1997965099 cites W2135457855 @default.
• W1997965099 cites W2143650397 @default.
• W1997965099 cites W2147329466 @default.
• W1997965099 cites W2148594304 @default.
• W1997965099 cites W2149696900 @default.
• W1997965099 cites W2152561234 @default.
• W1997965099 cites W2158753334 @default.
• W1997965099 cites W2158944729 @default.
• W1997965099 cites W2167299806 @default.
• W1997965099 cites W2299271935 @default.
• W1997965099 cites W2333719919 @default.
• W1997965099 cites W2441155430 @default.
• W1997965099 cites W2915473264 @default.
• W1997965099 doi "https://doi.org/10.1158/1078-0432.ccr-06-3031" @default.
• W1997965099 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2660867" @default.
• W1997965099 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17634540" @default.
• W1997965099 hasPublicationYear "2007" @default.
• W1997965099 type Work @default.
• W1997965099 sameAs 1997965099 @default.
• W1997965099 citedByCount "82" @default.
• W1997965099 countsByYear W19979650992012 @default.
• W1997965099 countsByYear W19979650992013 @default.
• W1997965099 countsByYear W19979650992014 @default.
• W1997965099 countsByYear W19979650992015 @default.
• W1997965099 countsByYear W19979650992016 @default.
• W1997965099 countsByYear W19979650992017 @default.
• W1997965099 countsByYear W19979650992018 @default.
• W1997965099 countsByYear W19979650992019 @default.
• W1997965099 countsByYear W19979650992020 @default.
• W1997965099 countsByYear W19979650992021 @default.
• W1997965099 countsByYear W19979650992022 @default.
• W1997965099 countsByYear W19979650992023 @default.
• W1997965099 crossrefType "journal-article" @default.
• W1997965099 hasAuthorship W1997965099A5000166823 @default.
• W1997965099 hasAuthorship W1997965099A5010536553 @default.
• W1997965099 hasAuthorship W1997965099A5012224683 @default.
• W1997965099 hasAuthorship W1997965099A5015634061 @default.
• W1997965099 hasAuthorship W1997965099A5020234995 @default.
• W1997965099 hasAuthorship W1997965099A5022477189 @default.
• W1997965099 hasAuthorship W1997965099A5030594142 @default.
• W1997965099 hasAuthorship W1997965099A5052299820 @default.
• W1997965099 hasAuthorship W1997965099A5056770711 @default.
• W1997965099 hasAuthorship W1997965099A5057040034 @default.

• next