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• W1997966377 abstract "1 The effects of histamine and specific histamine agonists has been examined on isolated longitudinal colon strips of guinea-pig and rat. 2 Histamine and 2-pyridyl-ethylamine but not 4 methylhistamine produced a concentration-related contractile response in the guinea-pig colon. 3 The H1-antagonist clemizole antagonized competitively the effect of histamine but the H2-antagonist ranitidine did not modify the dose-response curve to histamine in the guinea-pig colon. 4 Atropine, hexamethonium, prazosin and propranolol failed to modify the contractile response to histamine. 5 Tone induced with KCl in guinea-pig isolated colon was not modified by histamine agonists even in tissues pretreated with clemizole or ranitidine. 6 Histamine and histamine analogues were without effect on the isolated longitudinal strip of the rat colon. 7 It is concluded that histamine produced dose-dependent contractions of the guinea-pig colon due to direct activation of H1-histamine receptors. There is no evidence in favour of the existence of H2-histamine receptors in this preparation. The lack of effect of histamine agonists in rat colon strip argues against the existence of histamine receptors in this preparation." @default.
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• W1997966377 date "1986-07-01" @default.
• W1997966377 modified "2023-10-16" @default.
• W1997966377 title "Pharmacological investigation into the effects of histamine and histamine analogues on guinea-pig and rat colon in vitro" @default.
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• W1997966377 doi "https://doi.org/10.1111/j.1476-5381.1986.tb10229.x" @default.
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