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- W1997974709 abstract "<i>Background:</i> A severe form of fixed drug eruption (FDE) clinically and histologically mimics toxic epidermal necrolysis (TEN) but, unlike TEN, resolves spontaneously upon withdrawal of the causative drug. <i>Objective and Methods:</i> We reported a case of a severe FDE caused by mefenamic acid that spontaneously resolved without use of systemic corticosteroids. To clarify the phenotype of the T cells responsible for clinical resolution of FDE, we kinetically examined γ-interferon (IFN-γ), interleukin (IL)-2, IL-4 and IL-10 production by peripheral blood T cells of the patient before and after oral challenge with the causative drug using flow cytometry. <i>Results:</i> We found that the proportions of CD4+ and CD8+ T cells capable of producing IFN-γ and IL-4 remained unchanged after challenge, while those of CD4+ and CD8+ T cells capable of producing IL-10 dramatically increased after challenge. The frequency of CD8+ T cells capable of producing IL-2 decreased after challenge. <i>Conclusion:</i> These results suggest that expansion of IL-10-producing CD4+ and CD8+ T cells may be responsible for spontaneous resolution of a severe form of FDE." @default.
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- W1997974709 date "2006-01-01" @default.
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- W1997974709 title "Expansion of IL-10-Producing CD4+ and CD8+ T Cells in Fixed Drug Eruption" @default.
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- W1997974709 doi "https://doi.org/10.1159/000093845" @default.
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