Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997980103> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1997980103 endingPage "15" @default.
- W1997980103 startingPage "7" @default.
- W1997980103 abstract "Natalizumab is the first α4-integrin antagonist indicated for the treatment of relapsing multiple sclerosis (MS). Natalizumab has been shown to delay the accumulation of physical disability and reduce relapses. In two large, double-blind, randomized, placebo-controlled, phase 3 clinical trials, natalizumab was effective as a monotherapy as compared with placebo, and in combination with interferon β as compared with placebo and interferon β. Natalizumab in combination with glatiramer acetate was also effective in a phase 2 clinical trial when compared with placebo and glatiramer acetate. Natalizumab monotherapy achieved a 68% relative reduction in annualized relapse rate, and 42% and 54% reductions in disability progression sustained for 12 and 24 weeks, respectively. In a subset of patients with highly active disease, natalizumab proved more effective, decreasing relapse rates by 81% and progression of disability (sustained for 24 weeks) by 64%. Natalizumab-treated patients experienced significant improvements in quality of life, as measured by the Short Form-36, as well as a 35% reduction in risk of clinically significant vision loss. Recent analyses also have demonstrated the potential for natalizumab to induce a state of ‘no disease activity’ and actual improvement in physical disability. The purpose of this paper is to review evidence for the efficacy of natalizumab, and put its use in MS into perspective." @default.
- W1997980103 created "2016-06-24" @default.
- W1997980103 creator A5012376027 @default.
- W1997980103 creator A5063707894 @default.
- W1997980103 date "2009-11-01" @default.
- W1997980103 modified "2023-09-26" @default.
- W1997980103 title "Clinical efficacy and benefit of natalizumab" @default.
- W1997980103 cites W1514064771 @default.
- W1997980103 cites W1528299210 @default.
- W1997980103 cites W165055539 @default.
- W1997980103 cites W1839610592 @default.
- W1997980103 cites W1978838993 @default.
- W1997980103 cites W1980590617 @default.
- W1997980103 cites W1998423444 @default.
- W1997980103 cites W2002809692 @default.
- W1997980103 cites W2005506388 @default.
- W1997980103 cites W2012934594 @default.
- W1997980103 cites W2019582599 @default.
- W1997980103 cites W2023211244 @default.
- W1997980103 cites W2029637627 @default.
- W1997980103 cites W2032017965 @default.
- W1997980103 cites W2041912699 @default.
- W1997980103 cites W2052983324 @default.
- W1997980103 cites W2059114092 @default.
- W1997980103 cites W2061762188 @default.
- W1997980103 cites W2064017800 @default.
- W1997980103 cites W2071933656 @default.
- W1997980103 cites W2076343582 @default.
- W1997980103 cites W2077944387 @default.
- W1997980103 cites W2086344593 @default.
- W1997980103 cites W2103758700 @default.
- W1997980103 cites W2105053272 @default.
- W1997980103 cites W2105477343 @default.
- W1997980103 cites W2118704147 @default.
- W1997980103 cites W2127001605 @default.
- W1997980103 cites W2139367012 @default.
- W1997980103 cites W2164556363 @default.
- W1997980103 cites W2164564993 @default.
- W1997980103 cites W2165547142 @default.
- W1997980103 cites W2169098250 @default.
- W1997980103 cites W2324187974 @default.
- W1997980103 cites W4210548604 @default.
- W1997980103 cites W4234254101 @default.
- W1997980103 cites W4366064463 @default.
- W1997980103 doi "https://doi.org/10.1177/1352458509347129" @default.
- W1997980103 hasPublicationYear "2009" @default.
- W1997980103 type Work @default.
- W1997980103 sameAs 1997980103 @default.
- W1997980103 citedByCount "5" @default.
- W1997980103 countsByYear W19979801032016 @default.
- W1997980103 crossrefType "journal-article" @default.
- W1997980103 hasAuthorship W1997980103A5012376027 @default.
- W1997980103 hasAuthorship W1997980103A5063707894 @default.
- W1997980103 hasConcept C126322002 @default.
- W1997980103 hasConcept C142724271 @default.
- W1997980103 hasConcept C168563851 @default.
- W1997980103 hasConcept C203014093 @default.
- W1997980103 hasConcept C204787440 @default.
- W1997980103 hasConcept C27081682 @default.
- W1997980103 hasConcept C2778577042 @default.
- W1997980103 hasConcept C2780640218 @default.
- W1997980103 hasConcept C2781004633 @default.
- W1997980103 hasConcept C535046627 @default.
- W1997980103 hasConcept C71924100 @default.
- W1997980103 hasConcept C90924648 @default.
- W1997980103 hasConceptScore W1997980103C126322002 @default.
- W1997980103 hasConceptScore W1997980103C142724271 @default.
- W1997980103 hasConceptScore W1997980103C168563851 @default.
- W1997980103 hasConceptScore W1997980103C203014093 @default.
- W1997980103 hasConceptScore W1997980103C204787440 @default.
- W1997980103 hasConceptScore W1997980103C27081682 @default.
- W1997980103 hasConceptScore W1997980103C2778577042 @default.
- W1997980103 hasConceptScore W1997980103C2780640218 @default.
- W1997980103 hasConceptScore W1997980103C2781004633 @default.
- W1997980103 hasConceptScore W1997980103C535046627 @default.
- W1997980103 hasConceptScore W1997980103C71924100 @default.
- W1997980103 hasConceptScore W1997980103C90924648 @default.
- W1997980103 hasIssue "4_suppl" @default.
- W1997980103 hasLocation W19979801031 @default.
- W1997980103 hasOpenAccess W1997980103 @default.
- W1997980103 hasPrimaryLocation W19979801031 @default.
- W1997980103 hasRelatedWork W2013237798 @default.
- W1997980103 hasRelatedWork W2016896159 @default.
- W1997980103 hasRelatedWork W2071139866 @default.
- W1997980103 hasRelatedWork W2074618071 @default.
- W1997980103 hasRelatedWork W2078059558 @default.
- W1997980103 hasRelatedWork W2085438061 @default.
- W1997980103 hasRelatedWork W2130129275 @default.
- W1997980103 hasRelatedWork W2136628494 @default.
- W1997980103 hasRelatedWork W2523231025 @default.
- W1997980103 hasRelatedWork W31195842 @default.
- W1997980103 hasVolume "15" @default.
- W1997980103 isParatext "false" @default.
- W1997980103 isRetracted "false" @default.
- W1997980103 magId "1997980103" @default.
- W1997980103 workType "article" @default.