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- W1997983620 abstract "Fetal hepatocytes were harvested at 20 days of gestation from spontaneously hypertensive rats (SHR) and then transplanted into recipient adult SHR spleens. Morphological examination of the recipient spleens revealed that after 4 weeks, large masses of hepatocytes were present in the red pulp, as well as cord-like structures. Immunochemical determinations revealed that cytochrome P450 IVA1 (cytochrome P450 LAω) could be detected without any prior induction. Cytochrome P450 LAω was detected in fetal hepatocyte microsomes from the spleens 6 weeks after fetal hepatocyte transplantation. Cytochrome P450 LAω and peroxisomal acyl CoA oxidase were expressed 6 weeks after transplantation in a 70% hepatectomized host. These results demonstrate that fetal hepatocytes can be successfully transplanted to the spleens of recipient hosts, and that fetal hepatocytes appear to grow and develop functional cytochrome P450 metabolizing systems." @default.
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- W1997983620 date "1995-05-01" @default.
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- W1997983620 title "Effect of 70% partial hepatectomy on developmental expression of cytochrome P450 IVA1 within intrasplenically transplanted fetal hepatocytes from spontaneously hypertensive rats" @default.
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- W1997983620 doi "https://doi.org/10.1016/0928-4346(94)00187-a" @default.
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