FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997989669> ?p ?o ?g. }

• W1997989669 endingPage "1402" @default.
• W1997989669 startingPage "1394" @default.
• W1997989669 abstract "Lysophosphatidic acid (LPA) is a lipid mediator produced by adipocytes that acts via specific G-protein-coupled receptors; its synthesis is modulated in obesity. We previously reported that reducing adipocyte LPA production in high-fat diet (HFD)-fed obese mice is associated with improved glucose tolerance, suggesting a negative impact of LPA on glucose homeostasis. Here, our aim was to test this hypothesis. First, glucose tolerance and plasma insulin were assessed after acute (30 min) injection of LPA (50 mg/kg) or of the LPA1/LPA3 receptor antagonist Ki16425 (5 mg kg−1 day−1, i.p.) in non-obese mice fed a normal diet (ND) and in obese/prediabetic (defined as glucose-intolerant) HFD mice. Glucose and insulin tolerance, pancreas morphology, glycogen storage, glucose oxidation and glucose transport were then studied after chronic treatment (3 weeks) of HFD mice with Ki16425. In ND and HFD mice, LPA acutely impaired glucose tolerance by inhibiting glucose-induced insulin secretion. These effects were blocked by pre-injection of Ki16425 (5 mg/kg, i.p.). Inhibition of glucose-induced insulin secretion by LPA also occurred in isolated mouse islets. Plasma LPA was higher in HFD mice than in ND mice and Ki16425 transiently improved glucose tolerance. The beneficial effect of Ki16425 became permanent after chronic treatment and was associated with increased pancreatic islet mass and higher fasting insulinaemia. Chronic treatment with Ki16425 also improved insulin tolerance and increased liver glycogen storage and basal glucose use in skeletal muscle. Exogenous and endogenous LPA exerts a deleterious effect on glucose disposal through a reduction of plasma insulin; pharmacological blockade of LPA receptors improves glucose homeostasis in obese/prediabetic mice." @default.
• W1997989669 created "2016-06-24" @default.
• W1997989669 creator A5000455521 @default.
• W1997989669 creator A5006028113 @default.
• W1997989669 creator A5043172423 @default.
• W1997989669 creator A5046862355 @default.
• W1997989669 creator A5049779921 @default.
• W1997989669 creator A5050370164 @default.
• W1997989669 creator A5067815543 @default.
• W1997989669 creator A5074323505 @default.
• W1997989669 creator A5077913165 @default.
• W1997989669 creator A5088946409 @default.
• W1997989669 creator A5089436267 @default.
• W1997989669 date "2013-03-19" @default.
• W1997989669 modified "2023-10-12" @default.
• W1997989669 title "Lysophosphatidic acid impairs glucose homeostasis and inhibits insulin secretion in high-fat diet obese mice" @default.
• W1997989669 cites W1540310508 @default.
• W1997989669 cites W1824393510 @default.
• W1997989669 cites W1968814400 @default.
• W1997989669 cites W1980681655 @default.
• W1997989669 cites W1988523760 @default.
• W1997989669 cites W1993292710 @default.
• W1997989669 cites W1998134241 @default.
• W1997989669 cites W2008589619 @default.
• W1997989669 cites W2018638168 @default.
• W1997989669 cites W2025240578 @default.
• W1997989669 cites W2026202377 @default.
• W1997989669 cites W2032722121 @default.
• W1997989669 cites W2040769700 @default.
• W1997989669 cites W2056028922 @default.
• W1997989669 cites W2083368620 @default.
• W1997989669 cites W2090228141 @default.
• W1997989669 cites W2092205926 @default.
• W1997989669 cites W2098615703 @default.
• W1997989669 cites W2101134096 @default.
• W1997989669 cites W2116060153 @default.
• W1997989669 cites W2128585253 @default.
• W1997989669 cites W2131589278 @default.
• W1997989669 cites W2143959929 @default.
• W1997989669 cites W2149683086 @default.
• W1997989669 cites W2156472431 @default.
• W1997989669 cites W2156982258 @default.
• W1997989669 cites W2157654722 @default.
• W1997989669 cites W2159374668 @default.
• W1997989669 cites W2159623504 @default.
• W1997989669 cites W2163881287 @default.
• W1997989669 cites W2164717449 @default.
• W1997989669 cites W2205053345 @default.
• W1997989669 cites W3190064149 @default.
• W1997989669 doi "https://doi.org/10.1007/s00125-013-2891-3" @default.
• W1997989669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23508306" @default.
• W1997989669 hasPublicationYear "2013" @default.
• W1997989669 type Work @default.
• W1997989669 sameAs 1997989669 @default.
• W1997989669 citedByCount "68" @default.
• W1997989669 countsByYear W19979896692013 @default.
• W1997989669 countsByYear W19979896692014 @default.
• W1997989669 countsByYear W19979896692015 @default.
• W1997989669 countsByYear W19979896692016 @default.
• W1997989669 countsByYear W19979896692017 @default.
• W1997989669 countsByYear W19979896692018 @default.
• W1997989669 countsByYear W19979896692019 @default.
• W1997989669 countsByYear W19979896692020 @default.
• W1997989669 countsByYear W19979896692021 @default.
• W1997989669 countsByYear W19979896692022 @default.
• W1997989669 countsByYear W19979896692023 @default.
• W1997989669 crossrefType "journal-article" @default.
• W1997989669 hasAuthorship W1997989669A5000455521 @default.
• W1997989669 hasAuthorship W1997989669A5006028113 @default.
• W1997989669 hasAuthorship W1997989669A5043172423 @default.
• W1997989669 hasAuthorship W1997989669A5046862355 @default.
• W1997989669 hasAuthorship W1997989669A5049779921 @default.
• W1997989669 hasAuthorship W1997989669A5050370164 @default.
• W1997989669 hasAuthorship W1997989669A5067815543 @default.
• W1997989669 hasAuthorship W1997989669A5074323505 @default.
• W1997989669 hasAuthorship W1997989669A5077913165 @default.
• W1997989669 hasAuthorship W1997989669A5088946409 @default.
• W1997989669 hasAuthorship W1997989669A5089436267 @default.
• W1997989669 hasBestOaLocation W19979896691 @default.
• W1997989669 hasConcept C126322002 @default.
• W1997989669 hasConcept C134018914 @default.
• W1997989669 hasConcept C170493617 @default.
• W1997989669 hasConcept C17093226 @default.
• W1997989669 hasConcept C185592680 @default.
• W1997989669 hasConcept C2776661833 @default.
• W1997989669 hasConcept C2777391703 @default.
• W1997989669 hasConcept C2777499176 @default.
• W1997989669 hasConcept C2779306644 @default.
• W1997989669 hasConcept C2780833929 @default.
• W1997989669 hasConcept C3018667095 @default.
• W1997989669 hasConcept C63645605 @default.
• W1997989669 hasConcept C71924100 @default.
• W1997989669 hasConcept C86803240 @default.
• W1997989669 hasConceptScore W1997989669C126322002 @default.
• W1997989669 hasConceptScore W1997989669C134018914 @default.
• W1997989669 hasConceptScore W1997989669C170493617 @default.
• W1997989669 hasConceptScore W1997989669C17093226 @default.
• W1997989669 hasConceptScore W1997989669C185592680 @default.

• next