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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997990183> ?p ?o ?g. }

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• W1997990183 abstract "Nuclear targeting of bacterial proteins is an emerging pathogenic mechanism in bacteria. However, due to the absence of an appropriate screening system for nuclear targeting proteins, systematic approaches to nuclear targeting of bacterial proteins and subsequent host cell pathology are limited. In this study, we developed a screening system for nuclear targeting proteins in Acinetobacter baumannii using a combination of bioinformatic analysis based on nuclear localization signal (NLS) and the Gateway(®) recombinational cloning system. Among 3367 open reading frames of A. baumannii ATCC 17978, 34 functional or hypothetical proteins were predicted to carry the putative NLS sequences. Of the 29 clones generated by the Gateway(®) recombinational cloning system, 14 proteins tagged with green fluorescent protein (GFP) were targeted to nuclei of host cells. Among the 14 nuclear targeting proteins, S21, L20, and L32 ribosomal proteins and transposase carried putative nuclear export signal (NES) sequences, but only transposase harbored the functional NES. After translocation to nuclei of host cells, four A. baumannii proteins induced cytotoxicity. In conclusion, we have developed a screening system for nuclear targeting proteins in A. baumannii. This system may open the way to a new field of bacterial pathogenesis." @default.
• W1997990183 created "2016-06-24" @default.
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• W1997990183 date "2012-05-01" @default.
• W1997990183 modified "2023-09-26" @default.
• W1997990183 title "Screening of nuclear targeting proteins in Acinetobacter baumannii based on nuclear localization signals" @default.
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• W1997990183 doi "https://doi.org/10.1016/j.resmic.2012.02.001" @default.
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