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• W1997990704 abstract "Summary A review is given of the comparative pathology of endometrial carcinomas regarding the incidence, the morphology, and the relation with endometrial hyperplasia. Compared to man, endometrial carcinomas in animals are fairly rare, except in rabbits, in cattle, and in a slock of Hun: Wistar rats. In rabbits the endometrial carcinomas are mostly primary multiple and present in both horns. Histologically they are almost always adenocurcinomas. The histological structure can vary considerably with regard to the degree of differentiation. In cattle the endometrial carcinomas are mostly singular. Histologically they are mostly adenocurinomas. often accompanied by formation of much dense fibrous tissue. In rats the endometrial carcinomas are mostly primary multiple adenocaretnomas. In man as well as in the rabbit and in the rat, relationships have been described between endometrial hyperplasia and endometrial carcinoma. It is striking that in the dog, a species in which endometrial hyperplasia very often occurs, endometrial carcinomas should be rare. The endometrial carcinoma in the rabbit as an animal model for human endometrial carcinoma is discussed extensively. In both species there are signs indicating relationships between endometrial carcinomas and sex hormones, especially oestrogens. The incidence in rabbits is very high, Endometrial carcinomas in rabbits can be transplanted subcutaneously in the same rabbit. They can also he cultured in vitro. Moreover the rabbit is a suitable species to study the progesterone/progesterone‐receptor complex by determining the synthesis of the progesterone‐induced protein uteroglobin which may be important in studying endometrial carcinomas. Uteroglobin is a good murker for a functional’ Progesterone‐PR‐DNA‐mRNAug‐Uteroglobin‐System’ (or PUG‐System). Future research regarding the synthesis of uteroglobin in endometrial tissue of normal rabbits and in tumorous and nontumorous endometrial tissue of rabbits with endometrial carcinomas is discussed briefly." @default.
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• W1997990704 date "1984-09-01" @default.
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• W1997990704 title "Comparative pathology of endometrial carcinoma" @default.
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• W1997990704 doi "https://doi.org/10.1080/01652176.1984.9693937" @default.
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