Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997991641> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W1997991641 endingPage "243" @default.
- W1997991641 startingPage "235" @default.
- W1997991641 abstract "Summary Clostridium perfringens type A produces an enterotoxin that induces diarrhoea experimentally in man and animals. The enterotoxin causes increased membrane permeability in susceptible cells which is thought to be due to pore formation in the host cell membrane. The effect of purified C. perfringens enterotoxin on intact intestinal CaCO-2 monolayers was examined in Ussing chambers and on single cells by whole-cell patch clamp. Mucosal application of C. perfringens enterotoxin resulted in prompt increases in short-circuit current coupled with a reduction in transepithelial resistance consistent with movement of sodium and other cations smaller than diethanolamine from mucosa to serosa. These changes were independent of extracellular calcium. Increases in short-circuit current were also observed in the apical membranes of CaCO-2 monolayers permeabilised across the basolateral membrane with nystatin. Currents were blocked by subsequent exposure to mucosal barium and zinc. Zinc also prevented the development of the current increases in apical membranes. Cationic currents were also observed following exposure of single CaCO-2 cells in whole-cell patch clamp recordings. These data indicate that C. perfringens enterotoxin is able to form cation permeant pores in the apical membrane of human intestinal CaCO-2 epithelia and the increases in short-circuit current can be prevented by pre-exposure to zinc ions." @default.
- W1997991641 created "2016-06-24" @default.
- W1997991641 creator A5026697843 @default.
- W1997991641 creator A5043574037 @default.
- W1997991641 creator A5077324050 @default.
- W1997991641 creator A5079196991 @default.
- W1997991641 date "1999-03-01" @default.
- W1997991641 modified "2023-09-27" @default.
- W1997991641 title "Cationic currents induced by Clostridium perfringens type A enterotoxin in human intestinal CaCO-2 cells" @default.
- W1997991641 doi "https://doi.org/10.1099/00222615-48-3-235" @default.
- W1997991641 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10334590" @default.
- W1997991641 hasPublicationYear "1999" @default.
- W1997991641 type Work @default.
- W1997991641 sameAs 1997991641 @default.
- W1997991641 citedByCount "37" @default.
- W1997991641 countsByYear W19979916412013 @default.
- W1997991641 countsByYear W19979916412014 @default.
- W1997991641 countsByYear W19979916412015 @default.
- W1997991641 countsByYear W19979916412016 @default.
- W1997991641 countsByYear W19979916412017 @default.
- W1997991641 countsByYear W19979916412018 @default.
- W1997991641 countsByYear W19979916412019 @default.
- W1997991641 countsByYear W19979916412021 @default.
- W1997991641 crossrefType "journal-article" @default.
- W1997991641 hasAuthorship W1997991641A5026697843 @default.
- W1997991641 hasAuthorship W1997991641A5043574037 @default.
- W1997991641 hasAuthorship W1997991641A5077324050 @default.
- W1997991641 hasAuthorship W1997991641A5079196991 @default.
- W1997991641 hasBestOaLocation W19979916411 @default.
- W1997991641 hasConcept C104317684 @default.
- W1997991641 hasConcept C12554922 @default.
- W1997991641 hasConcept C147944092 @default.
- W1997991641 hasConcept C170493617 @default.
- W1997991641 hasConcept C185592680 @default.
- W1997991641 hasConcept C2779116991 @default.
- W1997991641 hasConcept C28406088 @default.
- W1997991641 hasConcept C3018436504 @default.
- W1997991641 hasConcept C41625074 @default.
- W1997991641 hasConcept C523546767 @default.
- W1997991641 hasConcept C54355233 @default.
- W1997991641 hasConcept C547475151 @default.
- W1997991641 hasConcept C55493867 @default.
- W1997991641 hasConcept C66999527 @default.
- W1997991641 hasConcept C86803240 @default.
- W1997991641 hasConcept C89423630 @default.
- W1997991641 hasConceptScore W1997991641C104317684 @default.
- W1997991641 hasConceptScore W1997991641C12554922 @default.
- W1997991641 hasConceptScore W1997991641C147944092 @default.
- W1997991641 hasConceptScore W1997991641C170493617 @default.
- W1997991641 hasConceptScore W1997991641C185592680 @default.
- W1997991641 hasConceptScore W1997991641C2779116991 @default.
- W1997991641 hasConceptScore W1997991641C28406088 @default.
- W1997991641 hasConceptScore W1997991641C3018436504 @default.
- W1997991641 hasConceptScore W1997991641C41625074 @default.
- W1997991641 hasConceptScore W1997991641C523546767 @default.
- W1997991641 hasConceptScore W1997991641C54355233 @default.
- W1997991641 hasConceptScore W1997991641C547475151 @default.
- W1997991641 hasConceptScore W1997991641C55493867 @default.
- W1997991641 hasConceptScore W1997991641C66999527 @default.
- W1997991641 hasConceptScore W1997991641C86803240 @default.
- W1997991641 hasConceptScore W1997991641C89423630 @default.
- W1997991641 hasIssue "3" @default.
- W1997991641 hasLocation W19979916411 @default.
- W1997991641 hasLocation W19979916412 @default.
- W1997991641 hasOpenAccess W1997991641 @default.
- W1997991641 hasPrimaryLocation W19979916411 @default.
- W1997991641 hasRelatedWork W18255195 @default.
- W1997991641 hasRelatedWork W1979308263 @default.
- W1997991641 hasRelatedWork W1997991641 @default.
- W1997991641 hasRelatedWork W1998088492 @default.
- W1997991641 hasRelatedWork W2292585853 @default.
- W1997991641 hasRelatedWork W2359811727 @default.
- W1997991641 hasRelatedWork W2885701830 @default.
- W1997991641 hasRelatedWork W2890318181 @default.
- W1997991641 hasRelatedWork W2895456838 @default.
- W1997991641 hasRelatedWork W2182469865 @default.
- W1997991641 hasVolume "48" @default.
- W1997991641 isParatext "false" @default.
- W1997991641 isRetracted "false" @default.
- W1997991641 magId "1997991641" @default.
- W1997991641 workType "article" @default.