Matches in SemOpenAlex for { <https://semopenalex.org/work/W1997991788> ?p ?o ?g. }
- W1997991788 endingPage "1509" @default.
- W1997991788 startingPage "1503" @default.
- W1997991788 abstract "Objectives To determine the impact of Plasmodium falciparum malaria coinfection and its treatment on cellular reservoirs of viral replication in HIV-1-infected persons and to relate this to changes in systemic immune activation. Methods Plasma samples were obtained from HIV-1-infected individuals (n = 10) at diagnosis of acute malaria, 4 weeks after parasite clearance and from HIV-infected aparasitemic controls (n = 10). Immunomagnetic HIV-1 capture analysis was used to determine the cellular origin of cell-free virus particles present in all 30 plasma samples and indices of immune activation were measured using enzyme-linked immunosorbent assays. Results Compared with controls, the detectable proportion of HIV-1 particles derived from CD14 macrophages and CD26 lymphocytes was increased in persons with acute malaria coinfection and correlated with markedly increased plasma concentrations of both proinflammatory cytokines and soluble markers of macrophage and lymphocyte activation. Parasite clearance following treatment with antimalarial drugs resulted in decreased detection of HIV-1 particles derived from the CD14 macrophage cell subset and correlated with a marked diminution in systemic immune activation. Conclusions Acute P. falciparum malaria coinfection impacts virus–host dynamics in HIV-1-infected persons at the cellular level, notably showing a reversible induction of HIV-1 replication in CD14 macrophages that is associated with changes in immune activation." @default.
- W1997991788 created "2016-06-24" @default.
- W1997991788 creator A5009618897 @default.
- W1997991788 creator A5032249049 @default.
- W1997991788 creator A5047551582 @default.
- W1997991788 creator A5067497118 @default.
- W1997991788 creator A5077855038 @default.
- W1997991788 creator A5079791559 @default.
- W1997991788 creator A5080716940 @default.
- W1997991788 date "2002-07-01" @default.
- W1997991788 modified "2023-10-12" @default.
- W1997991788 title "Immune activation and induction of HIV-1 replication within CD14 macrophages during acute Plasmodium falciparum malaria coinfection" @default.
- W1997991788 cites W1935280683 @default.
- W1997991788 cites W1976212756 @default.
- W1997991788 cites W1978141065 @default.
- W1997991788 cites W1981066689 @default.
- W1997991788 cites W2004319639 @default.
- W1997991788 cites W2009842286 @default.
- W1997991788 cites W2011630381 @default.
- W1997991788 cites W2022098233 @default.
- W1997991788 cites W2022130131 @default.
- W1997991788 cites W2027298939 @default.
- W1997991788 cites W2030051818 @default.
- W1997991788 cites W2042529296 @default.
- W1997991788 cites W2045042359 @default.
- W1997991788 cites W2048992492 @default.
- W1997991788 cites W2057442177 @default.
- W1997991788 cites W2063703736 @default.
- W1997991788 cites W2064130642 @default.
- W1997991788 cites W2100511655 @default.
- W1997991788 cites W2101912413 @default.
- W1997991788 cites W2105267808 @default.
- W1997991788 cites W2105522334 @default.
- W1997991788 cites W2115149972 @default.
- W1997991788 cites W2120880145 @default.
- W1997991788 cites W2124554623 @default.
- W1997991788 cites W2128965075 @default.
- W1997991788 cites W2147295679 @default.
- W1997991788 cites W2164909857 @default.
- W1997991788 cites W2314461521 @default.
- W1997991788 cites W2398572679 @default.
- W1997991788 cites W4236980275 @default.
- W1997991788 cites W9023311 @default.
- W1997991788 doi "https://doi.org/10.1097/00002030-200207260-00007" @default.
- W1997991788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12131188" @default.
- W1997991788 hasPublicationYear "2002" @default.
- W1997991788 type Work @default.
- W1997991788 sameAs 1997991788 @default.
- W1997991788 citedByCount "48" @default.
- W1997991788 countsByYear W19979917882012 @default.
- W1997991788 countsByYear W19979917882013 @default.
- W1997991788 countsByYear W19979917882014 @default.
- W1997991788 countsByYear W19979917882015 @default.
- W1997991788 countsByYear W19979917882020 @default.
- W1997991788 countsByYear W19979917882021 @default.
- W1997991788 countsByYear W19979917882022 @default.
- W1997991788 countsByYear W19979917882023 @default.
- W1997991788 crossrefType "journal-article" @default.
- W1997991788 hasAuthorship W1997991788A5009618897 @default.
- W1997991788 hasAuthorship W1997991788A5032249049 @default.
- W1997991788 hasAuthorship W1997991788A5047551582 @default.
- W1997991788 hasAuthorship W1997991788A5067497118 @default.
- W1997991788 hasAuthorship W1997991788A5077855038 @default.
- W1997991788 hasAuthorship W1997991788A5079791559 @default.
- W1997991788 hasAuthorship W1997991788A5080716940 @default.
- W1997991788 hasConcept C140704245 @default.
- W1997991788 hasConcept C159047783 @default.
- W1997991788 hasConcept C202751555 @default.
- W1997991788 hasConcept C203014093 @default.
- W1997991788 hasConcept C2522874641 @default.
- W1997991788 hasConcept C2777813720 @default.
- W1997991788 hasConcept C2778048844 @default.
- W1997991788 hasConcept C2778371730 @default.
- W1997991788 hasConcept C2778513237 @default.
- W1997991788 hasConcept C2779244956 @default.
- W1997991788 hasConcept C55493867 @default.
- W1997991788 hasConcept C86803240 @default.
- W1997991788 hasConcept C8891405 @default.
- W1997991788 hasConceptScore W1997991788C140704245 @default.
- W1997991788 hasConceptScore W1997991788C159047783 @default.
- W1997991788 hasConceptScore W1997991788C202751555 @default.
- W1997991788 hasConceptScore W1997991788C203014093 @default.
- W1997991788 hasConceptScore W1997991788C2522874641 @default.
- W1997991788 hasConceptScore W1997991788C2777813720 @default.
- W1997991788 hasConceptScore W1997991788C2778048844 @default.
- W1997991788 hasConceptScore W1997991788C2778371730 @default.
- W1997991788 hasConceptScore W1997991788C2778513237 @default.
- W1997991788 hasConceptScore W1997991788C2779244956 @default.
- W1997991788 hasConceptScore W1997991788C55493867 @default.
- W1997991788 hasConceptScore W1997991788C86803240 @default.
- W1997991788 hasConceptScore W1997991788C8891405 @default.
- W1997991788 hasIssue "11" @default.
- W1997991788 hasLocation W19979917881 @default.
- W1997991788 hasLocation W19979917882 @default.
- W1997991788 hasOpenAccess W1997991788 @default.
- W1997991788 hasPrimaryLocation W19979917881 @default.
- W1997991788 hasRelatedWork W177105905 @default.
- W1997991788 hasRelatedWork W1896517046 @default.